Outcome of Monochorionic Monoamniotic Twin Reversed Arterial Perfusion Sequence Diagnosed in the First Trimester

Weber, Eva Christin, Recker, Florian ORCID: 0000-0001-9135-4338, Gottschalk, Ingo, Strizek, Brigitte ORCID: 0000-0003-3625-7097, Geipel, Annegret, Gembruch, Ulrich ORCID: 0000-0001-8284-4669 and Berg, Christoph . Outcome of Monochorionic Monoamniotic Twin Reversed Arterial Perfusion Sequence Diagnosed in the First Trimester. Fetal Diagn. Ther.. BASEL: KARGER. ISSN 1421-9964

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DOI:10.1159/000519860

Abstract

Introduction: The aim of this study is to evaluate the outcome of pregnancies complicated by monochorionic monoamniotic twin reversed arterial perfusion sequence (MOMA TRAP) diagnosed in the first trimester. Methods: All patients diagnosed with MOMA TRAP sequence <14.0 weeks of gestation in a 10-year study period were retrospectively analyzed for intrauterine course and outcome. All patients were offered either expectant management or intrauterine intervention. Adverse outcome was defined as either intrauterine death (IUD), neonatal death or preterm birth Results: In the study period, 17 cases with MOMA TRAP sequence were diagnosed. Of these, 2 couples opted for termination of pregnancy. The remaining 15 were divided into 2 groups depending on the management: group A (n = 8) with expectant management and group B (n = 7) with intrauterine intervention. All fetuses in group A died before 20 weeks. Survival in group B was significantly better with 4/7 (57.1%) life births at a median of 39.6 weeks of gestation (p = 0.0256). The reasons for IUD in the 3 cases in group B were hemodynamic, strangulation, and bleeding complications during intervention. Conclusions: Intrauterine intervention in MOMA TRAP pregnancies significantly improves neonatal survival, although it is still associated with a substantial risk for IUD by hemodynamic complications or entanglement.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Weber, Eva Christin	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Recker, Florian	UNSPECIFIED	orcid.org/0000-0001-9135-4338	UNSPECIFIED
Gottschalk, Ingo	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Strizek, Brigitte	UNSPECIFIED	orcid.org/0000-0003-3625-7097	UNSPECIFIED
Geipel, Annegret	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Gembruch, Ulrich	UNSPECIFIED	orcid.org/0000-0001-8284-4669	UNSPECIFIED
Berg, Christoph	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED