Universität zu Köln

Schumann, Isabell, Berger, Michael, Nowag, Nadine, Schaefer, Yannick, Saumweber, Juliane, Scholz, Henrike and Thum, Andreas S. (2021). Ethanol-guided behavior in Drosophila larvae. Sci Rep, 11 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

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Abstract

Chemosensory signals allow vertebrates and invertebrates not only to orient in its environment toward energy-rich food sources to maintain nutrition but also to avoid unpleasant or even poisonous substrates. Ethanol is a substance found in the natural environment of Drosophila melanogaster. Accordingly, D. melanogaster has evolved specific sensory systems, physiological adaptations, and associated behaviors at its larval and adult stage to perceive and process ethanol. To systematically analyze how D. melanogaster larvae respond to naturally occurring ethanol, we examined ethanol-induced behavior in great detail by reevaluating existing approaches and comparing them with new experiments. Using behavioral assays, we confirm that larvae are attracted to different concentrations of ethanol in their environment. This behavior is controlled by olfactory and other environmental cues. It is independent of previous exposure to ethanol in their food. Moreover, moderate, naturally occurring ethanol concentration of 4% results in increased larval fitness. On the contrary, higher concentrations of 10% and 20% ethanol, which rarely or never appear in nature, increase larval mortality. Finally, ethanol also serves as a positive teaching signal in learning and memory and updates valence associated with simultaneously processed odor information. Since information on how larvae perceive and process ethanol at the genetic and neuronal level is limited, the establishment of standardized assays described here is an important step towards their discovery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schumann, Isabell UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Nowag, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Yannick UNSPECIFIED UNSPECIFIED UNSPECIFIED Saumweber, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Thum, Andreas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570487
DOI:	10.1038/s41598-021-91677-3
Journal or Publication Title:	Sci Rep
Volume:	11
Number:	1
Date:	2021
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALCOHOL-DEHYDROGENASE ADH; ENVIRONMENTAL ETHANOL; RESOURCE UTILIZATION; LEARNED BEHAVIOR; MELANOGASTER; TOLERANCE; MODEL; NEURONS; CIRCUIT; REWARD Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57048