Universität zu Köln

Zimmermann, Laura-Marie A. ORCID: 0000-0003-2126-9191, Correns, Annkatrin ORCID: 0000-0002-2197-1717, Furlan, Ariane G., Spanou, Chara E. S. and Sengle, Gerhard (2021). Controlling BMP growth factor bioavailability: The extracellular matrix as multi skilled platform. Cell. Signal., 85. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-3913

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Abstract

Bone morphogenetic proteins (BMPs) belong to the TGF-beta superfamily of signaling ligands which comprise a family of pluripotent cytokines regulating a multitude of cellular events. Although BMPs were originally discovered as potent factors extractable from bone matrix that are capable to induce ectopic bone formation in soft tissues, their mode of action has been mostly studied as soluble ligands in absence of the physiologically relevant cellular microenvironment. This micro milieu is defined by supramolecular networks of extracellular matrix (ECM) proteins that specifically target BMP ligands, present them to their cellular receptors, and allow their controlled release. Here we focus on functional interactions and mechanisms that were described to control BMP bioavailability in a spatio-temporal manner within the respective tissue context. Structural disturbance of the ECM architecture due to mutations in ECM proteins leads to dysregulated BMP signaling as underlying cause for connective tissue disease pathways. We will provide an overview about current mechanistic concepts of how aberrant BMP signaling drives connective tissue destruction in inherited and chronic diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zimmermann, Laura-Marie A. UNSPECIFIED orcid.org/0000-0003-2126-9191 UNSPECIFIED Correns, Annkatrin UNSPECIFIED orcid.org/0000-0002-2197-1717 UNSPECIFIED Furlan, Ariane G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spanou, Chara E. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sengle, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-571963
DOI:	10.1016/j.cellsig.2021.110071
Journal or Publication Title:	Cell. Signal.
Volume:	85
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-3913
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE MORPHOGENETIC PROTEINS; BETA-BINDING-PROTEINS; TGF-BETA; HEPARAN-SULFATE; TERNARY COMPLEX; PRO-REGION; FIBRILLIN-1; ACTIVATION; MYOSTATIN; MUSCLE Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57196