Bornstein, Bavat, Meltzer, Hagar, Adler, Ruth, Alyagor, Idan, Berkun, Victoria, Cummings, Gideon, Reh, Fabienne, Keren-Shaul, Hadas, David, Eyal, Riemensperger, Thomas and Schuldiner, Oren ORCID: 0000-0002-7350-9380 (2021). Transneuronal Dpr12/DIP-delta interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Embo J., 40 (12). HOBOKEN: WILEY. ISSN 1460-2075

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Abstract

The mechanisms controlling wiring of neuronal networks are not completely understood. The stereotypic architecture of the Drosophila mushroom body (MB) offers a unique system to study circuit assembly. The adult medial MB gamma-lobe is comprised of a long bundle of axons that wire with specific modulatory and output neurons in a tiled manner, defining five distinct zones. We found that the immunoglobulin superfamily protein Dpr12 is cell-autonomously required in gamma-neurons for their developmental regrowth into the distal gamma 4/5 zones, where both Dpr12 and its interacting protein, DIP-delta, are enriched. DIP-delta functions in a subset of dopaminergic neurons that wire with gamma-neurons within the gamma 4/5 zone. During metamorphosis, these dopaminergic projections arrive to the gamma 4/5 zone prior to gamma-axons, suggesting that gamma-axons extend through a prepatterned region. Thus, Dpr12/DIP-delta transneuronal interaction is required for gamma 4/5 zone formation. Our study sheds light onto molecular and cellular mechanisms underlying circuit formation within subcellular resolution.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bornstein, BavatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meltzer, HagarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adler, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alyagor, IdanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berkun, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cummings, GideonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reh, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keren-Shaul, HadasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
David, EyalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemensperger, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuldiner, OrenUNSPECIFIEDorcid.org/0000-0002-7350-9380UNSPECIFIED
URN: urn:nbn:de:hbz:38-572223
DOI: 10.15252/embj.2020105763
Journal or Publication Title: Embo J.
Volume: 40
Number: 12
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1460-2075
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57222

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