Universität zu Köln

Bornstein, Bavat, Meltzer, Hagar, Adler, Ruth, Alyagor, Idan, Berkun, Victoria, Cummings, Gideon, Reh, Fabienne, Keren-Shaul, Hadas, David, Eyal, Riemensperger, Thomas and Schuldiner, Oren ORCID: 0000-0002-7350-9380 (2021). Transneuronal Dpr12/DIP-delta interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Embo J., 40 (12). HOBOKEN: WILEY. ISSN 1460-2075

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Abstract

The mechanisms controlling wiring of neuronal networks are not completely understood. The stereotypic architecture of the Drosophila mushroom body (MB) offers a unique system to study circuit assembly. The adult medial MB gamma-lobe is comprised of a long bundle of axons that wire with specific modulatory and output neurons in a tiled manner, defining five distinct zones. We found that the immunoglobulin superfamily protein Dpr12 is cell-autonomously required in gamma-neurons for their developmental regrowth into the distal gamma 4/5 zones, where both Dpr12 and its interacting protein, DIP-delta, are enriched. DIP-delta functions in a subset of dopaminergic neurons that wire with gamma-neurons within the gamma 4/5 zone. During metamorphosis, these dopaminergic projections arrive to the gamma 4/5 zone prior to gamma-axons, suggesting that gamma-axons extend through a prepatterned region. Thus, Dpr12/DIP-delta transneuronal interaction is required for gamma 4/5 zone formation. Our study sheds light onto molecular and cellular mechanisms underlying circuit formation within subcellular resolution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bornstein, Bavat UNSPECIFIED UNSPECIFIED UNSPECIFIED Meltzer, Hagar UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Alyagor, Idan UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkun, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Cummings, Gideon UNSPECIFIED UNSPECIFIED UNSPECIFIED Reh, Fabienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Keren-Shaul, Hadas UNSPECIFIED UNSPECIFIED UNSPECIFIED David, Eyal UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemensperger, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuldiner, Oren UNSPECIFIED orcid.org/0000-0002-7350-9380 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572223
DOI:	10.15252/embj.2020105763
Journal or Publication Title:	Embo J.
Volume:	40
Number:	12
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1460-2075
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57222