Pernas, Lena 
ORCID: 0000-0002-4337-3435
(2021).
Cellular metabolism in the defense against microbes.
J. Cell Sci., 134 (5).
CAMBRIDGE:
COMPANY BIOLOGISTS LTD.
ISSN 1477-9137
Abstract
The study of metabolic changes associated with host-pathogen interactions have largely focused on the strategies that microbes use to subvert host metabolism to support their own proliferation. However, recent reports demonstrate that changes in host cell metabolism can also be detrimental to pathogens and restrict their growth. In this Review, I present a framework to consider how the host cell exploits the multifaceted roles of metabolites to defend against microbes. I also highlight how the rewiring of metabolic processes can strengthen cellular barriers to microbial invasion, regulate microbial virulence programs and factors, limit microbial access to nutrient sources and generate toxic environments for microbes. Collectively, the studies described here support a critical role for the rewiring of cellular metabolism in the defense against microbes. Further study of host-pathogen interactions from this framework has the potential to reveal novel aspects of host defense and metabolic control, and may inform how human metabolism impacts the progression of infectious disease.
| Item Type: | Journal Article | ||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-572251 | ||||||||
| DOI: | 10.1242/jcs.252023 | ||||||||
| Journal or Publication Title: | J. Cell Sci. | ||||||||
| Volume: | 134 | ||||||||
| Number: | 5 | ||||||||
| Date: | 2021 | ||||||||
| Publisher: | COMPANY BIOLOGISTS LTD | ||||||||
| Place of Publication: | CAMBRIDGE | ||||||||
| ISSN: | 1477-9137 | ||||||||
| Language: | English | ||||||||
| Faculty: | Unspecified | ||||||||
| Divisions: | Unspecified | ||||||||
| Subjects: | no entry | ||||||||
| Uncontrolled Keywords: |
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/57225 |
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