Universität zu Köln

von Spreckelsen, Niklas ORCID: 0000-0002-9873-1711, Waldt, Natalie, Timmer, Marco, Goertz, Lukas, Reinecke, David, Laukamp, Kai, Pennig, Lenhard, Grau, Stefan, Deckert, Martina, Kirches, Elmar, Stavrinou, Pantelis, Mawrin, Christian and Goldbrunner, Roland (2021). Clinical Characteristics and Magnetic Resonance Imaging-Based Prediction of the KLF4(K409Q) Mutation in Meningioma. World Neurosurg., 154. S. E665 - 6. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-8769

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Abstract

BACKGROUND: Meningioma is the most common primary brain tumor in adults. In recent years, several non-neurofibromin 2 mutations, i.e., AKT1, SMO, TRAF7, and KLF4 mutations, specific for meningioma have been identified. This study aims to analyze the clinical impact and imaging characteristics of the KLF4(K409Q) mutation in meningioma. METHODS: Clinical, neuropathologic, and imaging data of 170 patients who underwent meningioma resection between 2013 and 2018 were retrospectively collected and tumors were analyzed for the presence of the KLF4(K409Q) mutation. We collected imaging characteristics, performed volumetric analysis of tumor size and peritumoral edema (PTBE), and calculated the edema index (EI, i.e., ratio of PTBE to tumor volume). Receiver operating characteristic curve analysis was performed to identify cut-off EI values to predict the mutational status of KLF4. RESULTS: Eighteen (10.6%) of the meningiomas carried the KLF4(K409Q) mutation; these were significantly associated with a secretory subtype (P < 0.001) and sphenoid wing location (P = 0.029). Smaller tumor size (P = 0.007), an increased PTBE (P = 0.012), and an increased EI (P = 0.001) proved to be significantly associated with the KLF4(K409Q) mutation. In receiver operating characteristic curve analysis, EI predicted the KLF4(K409Q) mutation with an area under the curve of 0.728 (P = 0.0016). CONCLUSIONS: The KLF4(K409Q) mutation is associated with a distinct small tumor subtype, prone to substantial PTBE. EI is a reliable parameter to predict the KLF4(K409Q) mutation in meningioma, thus providing a tool for improvement of pre- and perioperative medical management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Spreckelsen, Niklas UNSPECIFIED orcid.org/0000-0002-9873-1711 UNSPECIFIED Waldt, Natalie UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmer, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinecke, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukamp, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Pennig, Lenhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirches, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED UNSPECIFIED UNSPECIFIED Mawrin, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572530
DOI:	10.1016/j.wneu.2021.07.119
Journal or Publication Title:	World Neurosurg.
Volume:	154
Page Range:	S. E665 - 6
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-8769
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SECRETORY MENINGIOMAS; BRAIN EDEMA; SKULL; TRAF7; KLF4 Multiple languages Clinical Neurology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57253