Universität zu Köln

Wang, Wanxue ORCID: 0000-0003-0606-6628, Todorov, Plamen ORCID: 0000-0003-3731-6116, Isachenko, Evgenia, Rahimi, Gohar, Mallmann, Peter, Wang, Mengying and Isachenko, Vladimir (2021). In vitro activation of cryopreserved ovarian tissue: A single-arm meta-analysis and systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol., 258. S. 258 - 265. AMSTERDAM: ELSEVIER. ISSN 1872-7654

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Abstract

Objective: Primordial follicles in premature ovarian failure (POF) patients are very difficult to be activated spontaneously, so that mature oocytes are difficult to be obtained for in vitro fertilization. The aim of our review is to analyze and to systematize the published data regarding effectiveness of different strategies for in vitro activation of cryopreserved ovarian tissue. Study design: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a review of the literature was performed for all relevant full-text articles published in PubMed in English. Meta-analysis conducted using STATA 14.0. The random-effects model was used to combine 8 study results because the examination of heterogeneity was minimal. Results: One hundred and seventy seven patients after in vitro activation treatment (IVA) of ovarian tissue had accumulatively 26 pregnancies through IVF or natural pregnancy and then produced 18 live births. The random-effects model showed that the total clinical pregnancy and baby born rates reported in 8 studies evidence about effectiveness of IVA. Conclusion: In vitro activation of primordial follicles as a new potential treatment for ovarian disorder patients, can be a promising option for fertility preservation. Drug-free activation of ovarian tissue in comparison with drug-included activation seemed to be more efficient. (C) 2021 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Wanxue UNSPECIFIED orcid.org/0000-0003-0606-6628 UNSPECIFIED Todorov, Plamen UNSPECIFIED orcid.org/0000-0003-3731-6116 UNSPECIFIED Isachenko, Evgenia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahimi, Gohar UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Mengying UNSPECIFIED UNSPECIFIED UNSPECIFIED Isachenko, Vladimir UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572683
DOI:	10.1016/j.ejogrb.2021.01.014
Journal or Publication Title:	Eur. J. Obstet. Gynecol. Reprod. Biol.
Volume:	258
Page Range:	S. 258 - 265
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-7654
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMORDIAL FOLLICLE ACTIVATION; OOCYTE-SPECIFIC DELETION; FERTILITY PRESERVATION; GROWTH; TRANSPLANTATION; PTEN; AUTOTRANSPLANTATION; STIMULATION; DISRUPTION; PATHWAY Multiple languages Obstetrics & Gynecology; Reproductive Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57268