Universität zu Köln

Arolt, Christoph ORCID: 0000-0002-6366-2285, Hoffmann, Franziska ORCID: 0000-0002-6872-924X, Nachtsheim, Lisa, Wolber, Philipp, Guntinas-Lichius, Orlando, Buettner, Reinhard, von Eggeling, Ferdinand ORCID: 0000-0002-8062-6999, Quaas, Alexander and Klussmann, Jens Peter . Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort. Head Neck Pathol.. NEW YORK: SPRINGER. ISSN 1936-0568

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Abstract

Procollagen 11A1 (COL11A1) is a central component of the extracellular matrix in many carcinomas, which is considered to be mainly produced by cancer associated fibroblasts (CAFs). As COL11A1 expression correlates with adverse prognosis and is implicated in chemoresistance, it is a promising putative target. For the first time, we used RNA in-situ hybridization to systematically identify the cells that produce COL11A1 in the ten most prevalent carcinoma types, lymphomas (n = 275) and corresponding normal tissue (n = 55; panCancer cohort). Moreover, as most salivary gland carcinomas (SGC) display distinct stromal architectures, we also analysed 110 SGC. The corresponding protein formation of COL11A1 was determined by MALDI-TOF-MS-Imaging. We report that colon, breast and salivary duct carcinomas are highly infiltrated by COL11A1 positive CAFs (CAFs(COL11A1)) and might thus be promising candidates for antidesmoplastic or COL11A1-targeted therapies. The amount of CAFs(COL11A1) correlated significantly with tumour grade, tumour stage and nodal spread in the panCancer cohort. Significant associations between CAFs(COL11A1) and vascular invasion, perineural spread and nodal spread were observed in the SGC cohort. Also, we discovered that tumour cells of intercalated duct derived SGC and CAFs produce COL11A1 in a mutually exclusive manner. Our findings represent a novel mode of extracellular matrix production in carcinomas and could be highly relevant in the future. Our findings elucidate the mode of COL11A1 expression in very different carcinoma types and may aid to categorise tumours in the setting of possible future COL11A1-related therapies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Arolt, Christoph UNSPECIFIED orcid.org/0000-0002-6366-2285 UNSPECIFIED Hoffmann, Franziska UNSPECIFIED orcid.org/0000-0002-6872-924X UNSPECIFIED Nachtsheim, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolber, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Guntinas-Lichius, Orlando UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED von Eggeling, Ferdinand UNSPECIFIED orcid.org/0000-0002-8062-6999 UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, Jens Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-573150
DOI:	10.1007/s12105-021-01370-0
Journal or Publication Title:	Head Neck Pathol.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1936-0568
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER; FIBROBLASTS; ALPHA-1(XI) Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57315