Kuetting, D., Luetkens, J., Faron, A., Isaak, A., Attenberger, U., Pieper, C. C., Meffert, L., Jansen, C., Sprinkart, A. and Kuetting, F. (2021). Evaluation of malignant effusions using MR-based T1 mapping. Sci Rep, 11 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

Full text not available from this repository.

Abstract

Our aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inversion-recovery sequence (TMIX) as reference. A total of 13 titrated albumin-solutions as well as 48 samples (29 ascites/pleural effusions from patients with malignancy; 19 from patients without malignancy) were examined. Samples were classified as malignant-positive histology, malignant-negative histology and non-malignant negative histology. In phantom analysis both mapping techniques correlated with albumin-content (MOLLI: r=-0.97, TMIX: r=-0.98). MOLLI T1 relaxation times were shorter in malignancy-positive histology fluids (2237 +/- 137 ms) than in malignancy-negative histology fluids (2423 +/- 357 ms) as well as than in non-malignant-negative histology fluids (2651 +/- 139 ms); post hoc test for all intergroup comparisons:<0.05. ROC analysis for differentiation between malignant and non-malignant effusions (malignant positive histology vs. all other) showed an (AUC) of 0.89 (95% CI 0.77-0.96). T1 mapping allows for non-invasive differentiation of malignant and non-malignant effusions in an ex-vivo set up.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kuetting, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luetkens, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faron, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isaak, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attenberger, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pieper, C. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meffert, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sprinkart, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuetting, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-573599
DOI: 10.1038/s41598-021-86632-1
Journal or Publication Title: Sci Rep
Volume: 11
Number: 1
Date: 2021
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DIAGNOSIS; RELAXATION; CTMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57359

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item