Universität zu Köln

Li, Yingchun, Hemmersbach, Lars, Krause, Bernhard, Sitnikov, Nikolay, Goederz, Anna Schlundt Nee, Maldonado, Diego O. Pastene, Schmalz, Hans-Gunther and Yard, Benito (2022). Head-to-Head Comparison of Selected Extra- and Intracellular CO-Releasing Molecules on Their CO-Releasing and Anti-Inflammatory Properties. ChemBioChem, 23 (1). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1439-7633

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Abstract

Over the past decade, a variety of carbon monoxide releasing molecules (CORMs) have been developed and tested. Some CORMs spontaneously release CO once in solution, while others require a trigger mechanism to release the bound CO from its molecular complex. The modulation of biological systems by CORMs depends largely on the spatiotemporal release of CO, which likely differs among the different types of CORMs. In spontaneously releasing CORMs, CO is released extracellularly and crosses the cell membrane to interact with intracellular targets. Other CORMs can directly release CO intracellularly, which may be a more efficient method to modulate biological systems. In the present study, we compared the efficacy of extracellular and intracellular CO-releasing CORMs that either release CO spontaneously or require an enzymatic trigger. The efficacy of such CORMs to modulate HO-1 and VCAM-1 expression in TNF-alpha-stimulated human umbilical vein endothelial cells (HUVEC) was evaluated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Yingchun UNSPECIFIED UNSPECIFIED UNSPECIFIED Hemmersbach, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Krause, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Sitnikov, Nikolay UNSPECIFIED UNSPECIFIED UNSPECIFIED Goederz, Anna Schlundt Nee UNSPECIFIED UNSPECIFIED UNSPECIFIED Maldonado, Diego O. Pastene UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Gunther UNSPECIFIED UNSPECIFIED UNSPECIFIED Yard, Benito UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-574050
DOI:	10.1002/cbic.202100452
Journal or Publication Title:	ChemBioChem
Volume:	23
Number:	1
Date:	2022
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1439-7633
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-ADHESION MOLECULE-1; CARBON-MONOXIDE; TRICARBONYL COMPLEXES; ET-CORMS; DESIGN; EXPRESSION; LINKER Multiple languages Biochemistry & Molecular Biology; Chemistry, Medicinal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57405