Universität zu Köln

Piper, Thomas, Geyer, Hans, Haenelt, Nadine, Huelsemann, Frank, Schaenzer, Wilhelm and Thevis, Mario (2021). Current Insights into the Steroidal Module of the Athlete Biological Passport. Int. J. Sports Med., 42 (10). S. 863 - 879. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3964

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Abstract

For decades, the class of anabolic androgenic steroids has represented the most frequently detected doping agents in athletes' urine samples. Roughly 50% of all adverse analytical findings per year can be attributed to anabolic androgenic steroids, of which about 2/3 are synthetic exogenous steroids, where a qualitative analytical approach is sufficient for routine doping controls. For the remaining 1/3 of findings, caused by endogenous steroid-derived analytical test results, a more sophisticated quantitative approach is required, as their sheer presence in urine cannot be directly linked to an illicit administration. Here, the determination of urinary concentrations and concentration ratios proved to be a suitable tool to identify abnormal steroid profiles. Due to the large inter-individual variability of both concentrations and ratios, population-based thresholds demonstrated to be of limited practicability, leading to the introduction of the steroidal module of the Athlete Biological Passport. The passport enabled the generation of athlete-specific individual reference ranges for steroid profile parameters. Besides an increase in sensitivity, several other aspects like sample substitution or numerous confounding factors affecting the steroid profile are addressed by the Athlete Biological Passport-based approach. This narrative review provides a comprehensive overview on current prospects, supporting professionals in sports drug testing and steroid physiology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Piper, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Haenelt, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Huelsemann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-574142
DOI:	10.1055/a-1481-8683
Journal or Publication Title:	Int. J. Sports Med.
Volume:	42
Number:	10
Page Range:	S. 863 - 879
Date:	2021
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3964
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOPING-CONTROL ANALYSIS; ENDOGENOUS STEROIDS; URINARY STEROIDS; INDUCED HYPERPROLACTINEMIA; TESTOSTERONE ESTERS; GAS-CHROMATOGRAPHY; REFERENCE RANGES; HUMAN SERUM; RATIO; PROFILE Multiple languages Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57414