Universität zu Köln

Piper, Thomas and Thevis, Mario (2022). Investigations in carbon isotope ratios of seized testosterone and boldenone preparations. Drug Test. Anal., 14 (3). S. 514 - 519. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

In order to detect the misuse of testosterone (T) or boldenone (Bo) in doping control analysis, the confirmation of atypical findings employing the determination of carbon isotope ratios (CIR) is mandatory for issuing adverse analytical findings. Elevated concentrations of T (or elevated T/epitestosterone ratios) may result from confounding factors such as ethanol intake, and the presence of low urinary concentrations of Bo can originate from endogenous or urinary in situ production of small amounts of the steroid. As pharmaceutical preparations of Bo and T are generally depleted in C-13, their CIR differ significantly from the C-13-enriched endogenous steroids. Some rare cases have been reported on pharmaceutical preparations showing C-13-enriched isotope ratios that complicate the current application of CIR in sports drug testing. Therefore, the CIR of a subset of n = 157 T preparations and n = 39 Bo preparations seized in Switzerland and Germany between 2013 and 2018 was analyzed in order to estimate the possible impact of steroid preparations showing C-13-enriched isotope ratios on the current approach to detect their misuse. All investigated Bo preparations showed CIR in the expected range between - 26.7 and -30.3 parts per thousand. Within the T samples, 95% showed the expected values below -26 parts per thousand while six samples fall between -25 and -26 parts per thousand and one sample was indistinguishable from endogenously produced T with a CIR of -23.3 parts per thousand.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Piper, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-574320
DOI:	10.1002/dta.3120
Journal or Publication Title:	Drug Test. Anal.
Volume:	14
Number:	3
Page Range:	S. 514 - 519
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language C-13/C-12 RATIOS; STEROIDS Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57432