Universität zu Köln

Rust, Katja and Wodarz, Andreas ORCID: 0000-0002-0007-6289 (2021). Transcriptional Control of Apical-Basal Polarity Regulators. Int. J. Mol. Sci., 22 (22). BASEL: MDPI. ISSN 1422-0067

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Abstract

Cell polarity is essential for many functions of cells and tissues including the initial establishment and subsequent maintenance of epithelial tissues, asymmetric cell division, and morphogenetic movements. Cell polarity along the apical-basal axis is controlled by three protein complexes that interact with and co-regulate each other: The Par-, Crumbs-, and Scrib-complexes. The localization and activity of the components of these complexes is predominantly controlled by protein-protein interactions and protein phosphorylation status. Increasing evidence accumulates that, besides the regulation at the protein level, the precise expression control of polarity determinants contributes substantially to cell polarity regulation. Here we review how gene expression regulation influences processes that depend on the induction, maintenance, or abolishment of cell polarity with a special focus on epithelial to mesenchymal transition and asymmetric stem cell division. We conclude that gene expression control is an important and often neglected mechanism in the control of cell polarity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rust, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Wodarz, Andreas UNSPECIFIED orcid.org/0000-0002-0007-6289 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-574628
DOI:	10.3390/ijms222212340
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	22
Number:	22
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASYMMETRIC CELL-DIVISION; HOX-INDUCED ORGANOGENESIS; ATYPICAL PKC; PAR COMPLEX; E-CADHERIN; PROTEIN; EXPRESSION; SNAIL; ADHESION; STEM Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57462