Universität zu Köln

Langerbeins, Petra and Eichhorst, Barbara (2021). Immune Dysfunction in Patients with Chronic Lymphocytic Leukemia and Challenges during COVID-19 Pandemic. Acta Haematol., 144 (5). S. 508 - 519. BASEL: KARGER. ISSN 1421-9662

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Abstract

The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been first described in December 2019 in Wuhan, China, and has led to a worldwide pandemic ever since. Initial clinical data imply that cancer patients are particularly at risk for a severe course of SARS-CoV-2. In patients with chronic lymphocytic leukemia (CLL), infections are a main contributor to morbidity and mortality driven by an impaired immune system. Treatment initiation is likely to induce immune modulation that further increases the risk for severe infections. This article aims to give an overview on pathogenesis and risk of infectious complications in patients with CLL. In this context, we discuss current data of SARS-CoV-2 infections in patients with CLL and how the pandemic impacts their management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langerbeins, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichhorst, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-574721
DOI:	10.1159/000514071
Journal or Publication Title:	Acta Haematol.
Volume:	144
Number:	5
Page Range:	S. 508 - 519
Date:	2021
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1421-9662
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57472