Universität zu Köln

Dettori, Rosalia, Milzi, Andrea, Frick, Michael, Burgmaier, Kathrin, Almalla, Mohammad ORCID: 0000-0003-4765-109X, Lubberich, Richard Karl, Marx, Nikolaus, Reith, Sebastian and Burgmaier, Mathias (2021). Lesion Geometry as Assessed by Optical Coherence Tomography Is Related to Myocardial Ischemia as Determined by Cardiac Magnetic Resonance Imaging. J. Clin. Med., 10 (15). BASEL: MDPI. ISSN 2077-0383

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Abstract

Introduction: Although the relationship between the geometry of coronary stenosis and the presence of myocardial ischemia is well known, the association between stenosis geometry and severity and/or extent of ischemia is still unexplored. Thus, we investigated this relationship using optical coherence tomography (OCT) to assess stenosis parameters and cardiac magnetic resonance imaging (CMR) to determine both extent and severity of ischemia. Methods: We analyzed 55 lesions from 51 patients with stable angina. Pre-interventionally, all patients underwent OCT-analysis of stenosis morphology as well as CMR to determine both the extent and severity of myocardial ischemia. Results: Percent area stenosis (%AS) was significantly associated with ischemic burden (r = 0.416, p = 0.003). Similar results could be obtained for other stenosis parameters as well as for several other parameters assessing the extent of ischemia. Furthermore, OCT-derived stenosis parameters were associated with the product of ischemic burden and severity of ischemia (%AS: r = 0.435, p = 0.002; similar results for other parameters). A Poiseuille's-law-modelled combination of stenosis length and minimal lumen diameter yielded a good diagnostic efficiency (AUC 0.787) in predicting an ischemic burden >10%. Conclusions: Our data highlight the key role of the geometry of coronary lesions in determining myocardial ischemia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dettori, Rosalia UNSPECIFIED UNSPECIFIED UNSPECIFIED Milzi, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Frick, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgmaier, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Almalla, Mohammad UNSPECIFIED orcid.org/0000-0003-4765-109X UNSPECIFIED Lubberich, Richard Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Marx, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Reith, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgmaier, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575345
DOI:	10.3390/jcm10153342
Journal or Publication Title:	J. Clin. Med.
Volume:	10
Number:	15
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FRACTIONAL FLOW RESERVE; CORONARY STENOSIS; MEDICAL THERAPY; PERFUSION; CRITERIA; PLAQUES; REVASCULARIZATION; RELEVANCE; DISEASE; IMPACT Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57534