Universität zu Köln

Niecke, Alexander ORCID: 0000-0002-4042-6693, Ramesh, Irene, Albus, Christian, Lungen, Markus, Pfaff, Holger ORCID: 0000-0001-9154-6575, Samel, Christina and Peters, Klaus M. (2021). Chronic Pain in People Impaired by Thalidomide Embryopathy: An Explorative Analysis of Prevalence, Pain Parameters and Biopsychosocial Factors. Psychother. Psychosom. Med. Psychol., 71 (09/10). S. 370 - 381. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-1058

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Abstract

Objective The aim of the study was to show the frequency, localisation, intensity, quality and degree of chronic pain in people with thalidomide-induced congenital defects (thalidomide embryopathy) and to investigate the association with biopsychosocial factors more closely. Methods A group of 202 people from North Rhine-Westphalia with thalidomide embryopathy were studied for the first time both physically for the pattern of the original damage and also psychiatrically in a structured diagnostic interview (SCID & SCID II). The results were combined with a standardized pain interview ( MPSS) and questionnaires on further pain-related (SF-36, painDETECT) and sociodemographic variables and analysed. In the analysis 167 completed datasets were included. Results The prevalence of pain in the sample population was 94 %. The majority (107, 54.0 %) already showed an advanced stage of chronicity in the MPSS: 63 subjects with Stage II (37.7 %) and 44 with Stage III (26.3 %). In 74 subjects (44.3 %) the PainDetect score showed a possible or neuropathic pain component. The factors that most reliably influenced the chronicity of pain proved to be hip pain (p < 0.001) and also mental health disorders (p = 0.001), above major depression (p < 0.001) and also somatic symptom disorders and substance-related disorders (p = 0.001 in each case). Social variables proved nonsignificant here (p = 0.094 for living alone, p = 0.122 for unemployment, p = 0.167 for lack of college education), as did the care situation (p = 0.191 for care dependency) and the underlying pattern of organ damage (p = 0.229 for damage to hearing, p = 0.764 for dysmelia). Conclusions People with thalidomide defects frequently suffer from a separate pain disorder which can be seen as secondary thalidomide-induced damage and which requires specialized and personalized multimodal pain management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Niecke, Alexander UNSPECIFIED orcid.org/0000-0002-4042-6693 UNSPECIFIED Ramesh, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED Albus, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lungen, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfaff, Holger UNSPECIFIED orcid.org/0000-0001-9154-6575 UNSPECIFIED Samel, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Klaus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575702
DOI:	10.1055/a-1457-2846
Journal or Publication Title:	Psychother. Psychosom. Med. Psychol.
Volume:	71
Number:	09/10
Page Range:	S. 370 - 381
Date:	2021
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-1058
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIFE; DISORDERS Multiple languages Psychology, Clinical Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57570