Universität zu Köln

Koksal, Muammer Osman ORCID: 0000-0001-8411-2795, Akguel, Baki, Beka, Hayati, Ciftci, Sevgi, Keskin, Fahriye, Eraksoy, Haluk and Agacfidan, Ali (2021). Frequency of CCR5-Delta 32, CCR2-64I and SDF1-3 ' A alleles in HIV-infected and uninfected patients in Istanbul, Turkey. J. Infect. Dev. Ctries., 15 (8). S. 1183 - 1190. TRAMANIGLIO: J INFECTION DEVELOPING COUNTRIES. ISSN 1972-2680

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Abstract

Introduction: Co-receptors involved in cell entry of the human immunodeficiency virus (HIV) and mutations in genes encoding their ligands may play a role in the susceptibility to infection and resistance to the progression of the infection. The best studied mutations that can exist in these genes are the CCR5-Delta 32, CCR2-64I and SDF1-3'A mutations. The frequency of these mutations vary from continent to continent and even from region to region. However, there is limited information on their distribution throughout the Turkish population. Istanbul is the city with the highest number of documented HIV-infected patients in Turkey, which can be attributed to the population size. The aim of this study was to determine the distribution of three AIDS-related gene variants among HIV-infected and uninfected population in Istanbul, Turkey and to estimate the contribution of these variants to susceptibility or resistance to HIV. Methodology: A total of 242 healthy individuals and 200 HIV-positive patients were included in the study. CCR5 polymorphisms were genotyped by polymerase chain reaction. CCR2 and SDF1 polymorphisms were genotyped using PCR restriction fragment length polymorphism (PCR-RFLP). Results: The allelic frequencies for CCR5-Delta 32, CCR2-64I and SDF1-3'A were 4.07%, 19.8% and 28.7%, respectively. No individual was found to carry the homozygous CCR5-Delta 32 mutation in either cohort. No polymorphism was found to be significantly elevated in the HIV-infected cohort compared to the healthy group. Conclusions: The distribution of CCR5-Delta 32, CCR2-64I, and SDF1-3'A variants does not differ between HIV-infected and uninfected patients. CCR2-64I and SDF1-3'A frequencies are relatively high where as the frequency of CCR5-Delta 32 is low.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koksal, Muammer Osman UNSPECIFIED orcid.org/0000-0001-8411-2795 UNSPECIFIED Akguel, Baki UNSPECIFIED UNSPECIFIED UNSPECIFIED Beka, Hayati UNSPECIFIED UNSPECIFIED UNSPECIFIED Ciftci, Sevgi UNSPECIFIED UNSPECIFIED UNSPECIFIED Keskin, Fahriye UNSPECIFIED UNSPECIFIED UNSPECIFIED Eraksoy, Haluk UNSPECIFIED UNSPECIFIED UNSPECIFIED Agacfidan, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575769
DOI:	10.3855/jidc.12861
Journal or Publication Title:	J. Infect. Dev. Ctries.
Volume:	15
Number:	8
Page Range:	S. 1183 - 1190
Date:	2021
Publisher:	J INFECTION DEVELOPING COUNTRIES
Place of Publication:	TRAMANIGLIO
ISSN:	1972-2680
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHEMOKINE RECEPTOR GENE; POLYMORPHISMS; CCR5; RESISTANCE; VARIANTS; SUSCEPTIBILITY; PROTECTION; SDF-1 Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57576