Universität zu Köln

Martakis, Kyriakos ORCID: 0000-0003-3982-0914, Stark, Christina, Rehberg, Mirko, Jackels, Miriam, Schoenau, Eckhard and Duran, Ibrahim ORCID: 0000-0003-4044-8822 (2021). Association of muscle mass and fat mass on low- density-lipoprotein cholesterol and triglyceride plasma concentration in children and adolescents. J. Pediatr. Endocrinol. Metab., 34 (10). S. 1273 - 1283. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2191-0251

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Abstract

Objectives: Obesity has often been associated with high low-density-lipoprotein cholesterol (LDL-C) and triglycer-ide plasma concentrations, known risk factors for diabetes mellitus and cardiovascular disease. Study objective was to evaluate the association of LDL-C and triglyceride plasma concentration with muscle and fat mass in children and adolescents. Methods: We analyzed data of the National Health and Nutrition Examination Survey (1999-2004) to estimate lean muscle and fat mass assessed by dual-energy X-ray absorptiometry (DXA) of participants whose lipid profiles had been examined. Fat mass was operationalized by DXA-determined fat mass index (FMI). Muscle mass was assessed by appendicular lean mass index (aLMI). High LDL-C and triglyceride concentration was defined as above 130 mg/dL. Results: For the evaluation of the association of LDL-C and triglyceride plasma concentration with LMI and FMI Z-scores, the data of 2,487 children and adolescents (age 8-19 years) (984 females) were eligible. High aLMI showed no association with LDL-C or triglyceride concentration, but high FMI showed significant association with LDL-C and triglyceride plasma concentration in the bivariate regression analysis. Conclusions: Isolated muscle mass increase may not be protective against high LDL-C and triglycerides plasma levels in children and adolescents. Thus, exercise may lead to risk factor reduction mainly through fat mass reduction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Martakis, Kyriakos UNSPECIFIED orcid.org/0000-0003-3982-0914 UNSPECIFIED Stark, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehberg, Mirko UNSPECIFIED UNSPECIFIED UNSPECIFIED Jackels, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Duran, Ibrahim UNSPECIFIED orcid.org/0000-0003-4044-8822 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576129
DOI:	10.1515/jpem-2021-0254
Journal or Publication Title:	J. Pediatr. Endocrinol. Metab.
Volume:	34
Number:	10
Page Range:	S. 1273 - 1283
Date:	2021
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2191-0251
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language X-RAY ABSORPTIOMETRY; PERCENT BODY-FAT; RISK-FACTORS; WAIST CIRCUMFERENCE; LDL; LIPIDS; ADIPOSITY; MORTALITY; OBESITY; HEALTH Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57612