Universität zu Köln

Csordas, Gabor ORCID: 0000-0001-6871-6839, Gabor, Erika and Honti, Viktor (2021). There and back again: The mechanisms of differentiation and transdifferentiation in Drosophila blood cells. Dev. Biol., 469. S. 135 - 144. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-564X

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Abstract

Transdifferentiation is a conversion of an already differentiated cell type into another cell type without the involvement of stem cells. This transition is well described in the case of vertebrate immune cells, as well as in Drosophila melanogaster, which therefore serves as a suitable model to study the process in detail. In the Drosophila larva, the latest single-cell sequencing methods enabled the clusterization of the phagocytic blood cells, the plasmatocytes, which are capable of transdifferentiation into encapsulating cells, the lamellocytes. Here we summarize the available data of the past years on the plasmatocyte-lamellocyte transition, and make an attempt to harmonize them with transcriptome-based blood cell clustering to better understand the underlying mechanisms of transdifferentiation in Drosophila, and in general.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Csordas, Gabor UNSPECIFIED orcid.org/0000-0001-6871-6839 UNSPECIFIED Gabor, Erika UNSPECIFIED UNSPECIFIED UNSPECIFIED Honti, Viktor UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576296
DOI:	10.1016/j.ydbio.2020.10.006
Journal or Publication Title:	Dev. Biol.
Volume:	469
Page Range:	S. 135 - 144
Date:	2021
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-564X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELLULAR IMMUNE-RESPONSE; HEMOCYTE LINEAGES; HEMATOPOIETIC PROGENITORS; MATRIX PROTEIN; LYMPH GLAND; B-CELLS; RECEPTOR; REVEALS; PHAGOCYTOSIS; PLASTICITY Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57629