Universität zu Köln

Fan, Ningbo ORCID: 0000-0002-1622-6747, Wang, Zhen, Huang, Yuanheng, Tan, Zihui, Yang, Han and Lin, Peng (2021). A Retrospective Study of 52 Patients With Primary Small Cell Carcinoma of the Esophagus Treated With Radical Surgery. Cancer Control, 28. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1073-2748

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Abstract

Background: Primary small cell carcinoma of the esophagus (SCCE) is a rare and extremely fatal disease. We aim to evaluate the efficacy of radical surgery for resectable SCCE and to explore potential prognostic factors. Methods: We retrospectively reviewed 52 consecutive SCCE patients who underwent radical surgery from February 1993 to November 2014 at a single institution. The Kaplan-Meier estimator with log-rank test was used to assess overall survival (OS), disease-free survival (DFS) and median survival time. Univariate and multivariable analyses were used to evaluate prognostic factors through Cox proportional hazard regression model. Results: Twenty-five (48.1%) patients were treated with surgery alone, whereas 27 (51.9%) patients underwent adjuvant therapy after surgery. The median OS time was 17.4 months (95% CI: 13.5-21.3). The median DFS time was 13.4 months (95% CI: 7.7-19.0). Patients whose tumors were located in the lower part of thoracic esophagus and the esophagogastric junction showed significantly better OS (27.0 vs. 13.2 months, P = 0.016) and DFS (27.0 vs. 11.3 months, P = 0.017) than those located in the upper and middle parts. Patients with N0 status experienced significantly better OS (21.4 vs. 11.6 months, P = 0.012) and DFS (21.4 vs. 8.6 months, P = 0.012) than those with N+ status. Patients whose tumor lengths were shorter than 5 cm had a better OS (17.4 vs. 5.7 months, P = 0.035) than those longer than 5 cm. Patients who underwent chemotherapy experienced a significantly improved OS (21.0 vs. 14.1 months, P = 0.032) compared to surgery alone. Multivariable analysis showed that lower tumor location, shorter tumor length, pN0 status and chemotherapy independently predicted better OS; lower tumor location and pN0 status independently predicted better DFS. Conclusions: Radical surgery in combination with chemotherapy has better outcomes than surgery alone for resectable SCCE. Higher tumor location, longer tumor length, lymph node metastasis and not undergoing chemotherapy independently predict worse prognoses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fan, Ningbo UNSPECIFIED orcid.org/0000-0002-1622-6747 UNSPECIFIED Wang, Zhen UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Yuanheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Tan, Zihui UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Han UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Peng UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576307
DOI:	10.1177/10732748211027147
Journal or Publication Title:	Cancer Control
Volume:	28
Date:	2021
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	1073-2748
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERT CONSENSUS; MANAGEMENT; TUMOR; CANCER; RADIOTHERAPY; INSTITUTION; PROGNOSIS; SURVIVAL; DISEASE; LENGTH Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57630