Universität zu Köln

Wieja, Franziska ORCID: 0000-0002-4993-7967, Jacobs, Georg ORCID: 0000-0002-7564-288X, Stein, Sebastian ORCID: 0000-0002-9484-6036, Kopp, Alexander ORCID: 0000-0001-8787-0401, van Gaalen, Kerstin ORCID: 0000-0001-8311-5011, Kroger, Nadja and Zinser, Max (2022). Development and validation of a parametric human mandible model to determine internal stresses for the future design optimization of maxillofacial implants. J. Mech. Behav. Biomed. Mater., 125. AMSTERDAM: ELSEVIER. ISSN 1878-0180

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Abstract

Large segmental mandible bone defects still represent a challenge for endogenous regeneration. Despite the bone's capacity to heal in many clinical situations, bone defects over a critical size do not heal spontaneously. An emerging treatment of critically sized mandibular defects is the implantation of individually manufactured scaffolds consisting of biodegradable magnesium alloys. Biomedical engineers faced the challenge of developing a scaffold structure that not only provides sufficient stability, but also stimulates and promotes bone growth while considering the degradation of the magnesium alloy. The porosity of the scaffold must also support bone ingrowth and neovascularization. For an optimal design and subsequent structural optimization knowledge of external load cases is essential. However, currently the muscle and joint forces of the mandible cannot be measured directly. The aim of our study was therefore the development of a parametric human mandible model to determine the relevant boundary conditions for the subsequent structural optimization of individual jawbone implants. Using a model-based approach, determining the essential external load of the mandible as a function of the age and sex of a patient individually and the realistic simulation of the mechanical stress for patient-specific loads and anatomies has been realized. The developed model is successfully validated by evaluating the deformations and stresses of the lower jaw of a possible patient and comparing them with the results of dental research. Based on the results of the modelling, in a subsequent optimization process section forces at the interface between the bone tissue and jawbone implant can be determined and used to optimize the design of the jawbone implant.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wieja, Franziska UNSPECIFIED orcid.org/0000-0002-4993-7967 UNSPECIFIED Jacobs, Georg UNSPECIFIED orcid.org/0000-0002-7564-288X UNSPECIFIED Stein, Sebastian UNSPECIFIED orcid.org/0000-0002-9484-6036 UNSPECIFIED Kopp, Alexander UNSPECIFIED orcid.org/0000-0001-8787-0401 UNSPECIFIED van Gaalen, Kerstin UNSPECIFIED orcid.org/0000-0001-8311-5011 UNSPECIFIED Kroger, Nadja UNSPECIFIED UNSPECIFIED UNSPECIFIED Zinser, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576405
DOI:	10.1016/j.jmbbm.2021.104893
Journal or Publication Title:	J. Mech. Behav. Biomed. Mater.
Volume:	125
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1878-0180
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ISOMETRIC BITE FORCE; MATHEMATICAL-MODEL; BONE Multiple languages Engineering, Biomedical; Materials Science, Biomaterials Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57640