Universität zu Köln

Karapanos, Leonidas ORCID: 0000-0001-7608-7673, Akbarov, Ilgar ORCID: 0000-0002-1487-8696, Zugor, Vahudin, Kokx, Ruud, Hagemeier, Anna and Heidenreich, Axel (2021). Safety and mid-term surgical results of anterior urethroplasty with the tissue-engineered oral mucosa graft MukoCell(R): A single-center experience. Int. J. Urol., 28 (9). S. 936 - 943. HOBOKEN: WILEY. ISSN 1442-2042

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Abstract

Objective To assess the mid-term efficacy and safety of anterior urethroplasty using an autologous tissue-engineered oral mucosa graft (MukoCell(R)). Methods The data of 77 patients with anterior urethral strictures undergoing treatment with MukoCell(R) at a tertiary center from June 2016 to May 2019 were analyzed. Patients' characteristics, pre- and postoperative diagnostics, perioperative complications, and follow-up data were obtained. The overall stricture-free survival, outcomes of the different surgical techniques, stricture localizations, stricture length, early complications of the procedure and risk factors of recurrence were assessed. Results The median follow-up period was 38 months (interquartile range 31-46). The overall recurrence-free rate of anterior urethroplasty using MukoCell(R) was 68.8%, 24 patients (31.2%) developed a recurrence of the stricture. The stricture recurrences were observed at a median of 7 months (interquartile range 3-13) only in patients with at least one previous surgery or repeated dilatations in their medical history. No oral-urethral adverse events related to the use of MukoCell(R) were observed, except for a urethrocutaneous fistula (1.3%) requiring reoperation. Conclusions Anterior one-stage urethroplasty using MukoCell(R) showed in our hands a mid-term success rate of up to 68.8% without significant adverse events after a median follow-up period of 38 months. This procedure might be an alternative option for long-segment urethral reconstruction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Karapanos, Leonidas UNSPECIFIED orcid.org/0000-0001-7608-7673 UNSPECIFIED Akbarov, Ilgar UNSPECIFIED orcid.org/0000-0002-1487-8696 UNSPECIFIED Zugor, Vahudin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kokx, Ruud UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagemeier, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576836
DOI:	10.1111/iju.14606
Journal or Publication Title:	Int. J. Urol.
Volume:	28
Number:	9
Page Range:	S. 936 - 943
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1442-2042
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language URETHRAL STRICTURE; AUTOLOGOUS GRAFT; HYPOSPADIAS; DISEASE Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57683