Universität zu Köln

Eghbalzadeh, Kaveh, Guschlbauer, Maria, Weber, Carolyn, Wacker, Max Theodor, Reinhardt, Stefanie, Djordjevic, Ilija ORCID: 0000-0002-5810-8626, Sabashnikov, Anton, Maul, Alexandra, Sterner-Kock, Anja, Wahlers, Thorsten C. W., Scherner, Maximilian and Wippermann, Jens (2021). Experimental Studies for Small Diameter Grafts in an In Vivo Sheep Model-Techniques and Pitfalls. Thorac. Cardiovasc. Surg., 69 (7). S. 649 - 660. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-1902

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Abstract

Background Scientific attempts to create the ideal small diameter vascular graft have been compared with the search of the holy grail. Prosthetic material as expanded polytetrafluoroethylene or Dacron shows acceptable patency rates to large caliber vessels, while small diameter (< 6 mm) prosthetic conduits present unacceptably poor patency rates. Vascular tissue engineering represents a promising option to address this problem. Material and Methods Thirty-two female Texel-sheep aged 6 months to 2 years underwent surgical common carotid artery (CCA) interposition using different tissue-engineered vascular substitutes. Explantation of the grafts was performed 12 ( n = 12) and 36 ( n = 20) weeks after surgery. Ultrasound was performed on postoperative day 1 and thereafter every 4 weeks to evaluate the graft patency. Results The average length of implanted substitutes was 10.3 +/- 2.2 cm. Anesthesia and surgical procedure could be performed without major surgical complications in all cases. The grafts showed a systolic blood flow velocity (BFV) of 28.24 +/- 13.5 cm/s, a diastolic BFV of 9.25 +/- 4.53 cm/s, and a mean BFV of 17.85 +/- 9.25 cm/s. Native vessels did not differ relevantly in hemodynamic measurements (systolic: 29.77 cm/s; diastolic: 7.99 cm/s +/- 5.35; mean 15.87 +/- 10.75). There was no incidence of neurologic complications or subsequent postoperative occlusion. Perioperative morbidity was low and implantation of conduits was generally well tolerated. Conclusion This article aims to give a precise overview of in vivo experiments in sheep for the evaluation of small diameter vascular grafts performing CCA interposition, especially with regard to pitfalls and possible perioperative complications and to discuss advantages and disadvantages of this approach.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eghbalzadeh, Kaveh UNSPECIFIED UNSPECIFIED UNSPECIFIED Guschlbauer, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Carolyn UNSPECIFIED UNSPECIFIED UNSPECIFIED Wacker, Max Theodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhardt, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Djordjevic, Ilija UNSPECIFIED orcid.org/0000-0002-5810-8626 UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Maul, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Sterner-Kock, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten C. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherner, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wippermann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576998
DOI:	10.1055/s-0039-1687887
Journal or Publication Title:	Thorac. Cardiovasc. Surg.
Volume:	69
Number:	7
Page Range:	S. 649 - 660
Date:	2021
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-1902
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANIMAL-MODELS; POLYTETRAFLUOROETHYLENE GRAFTS; COAGULATION PARAMETERS; VERTEBRAL ARTERIES; VASCULAR GRAFT; BLOOD FLOW; PATENCY; PROSTHESES; AGGREGATION; CIRCULATION Multiple languages Cardiac & Cardiovascular Systems; Respiratory System; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57699