Universität zu Köln

Zubarevich, Alina ORCID: 0000-0002-2444-5747, Zhigalov, Konstantin, Szczechowicz, Marcin, Rad, Arian Arjomandi ORCID: 0000-0002-4931-4049, Vardanyan, Robert, Torabi, Saeed, Papathanasiou, Maria, Luedike, Peter, Koch, Achim ORCID: 0000-0002-1616-4873, Pizanis, Nikolaus, Kamler, Markus, Schmack, Bastian, Ruhparwar, Arjang and Weymann, Alexander (2022). Rescue extracorporeal life support as a bridge to durable left ventricular assist device. Int. J. Artif. Organs, 45 (4). S. 371 - 379. LONDON: SAGE PUBLICATIONS LTD. ISSN 1724-6040

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Abstract

Background: The ideal timing of a durable assist device implantation in patients with end-stage heart failure presenting with INTERMACS profile I is still controversial. The data on extracorporeal life support (ECLS) bridge to durable left ventricular assist device (LVAD) in these patients is limited. Materials and methods: We retrospectively analyzed the outcomes of 35 patients in acute cardiogenic shock (CS) who, between December 2013 and September 2020, were bridged with ECLS to durable LVAD. The mean age was 52.3 +/- 12.0 years. The primary endpoints of this study were in-hospital, 30-day, 6-month, and 1-year mortality. The secondary endpoint was the development of any postoperative adverse events and other characteristics during the follow-up period. We also assessed the impact of the rescue ECLS on the recovery of the end-organ function. Results: In-hospital, 30-day, 6-month, and 1-year survival was 65.6%, 75.9%, 69.2%, and 62.7% respectively. The median time on ECLS was 7 days (IQR 5.0-13.0). We observed a high incidence of a severe right heart failure (22.9%), acute kidney injury on dialysis (68.6%), and respiratory failure (77.1%). Bridge with ECLS provided a significant recovery of liver and kidney function prior to durable LVAD implantation. Conclusion: The concept of bridging patients presenting in end-stage heart failure and cardiogenic shock with ECLS prior to durable LVAD implantation is a feasible method to ensure acceptable survival rates and significant recovery of the end-organ function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zubarevich, Alina UNSPECIFIED orcid.org/0000-0002-2444-5747 UNSPECIFIED Zhigalov, Konstantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Szczechowicz, Marcin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rad, Arian Arjomandi UNSPECIFIED orcid.org/0000-0002-4931-4049 UNSPECIFIED Vardanyan, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Torabi, Saeed UNSPECIFIED UNSPECIFIED UNSPECIFIED Papathanasiou, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Luedike, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Achim UNSPECIFIED orcid.org/0000-0002-1616-4873 UNSPECIFIED Pizanis, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmack, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhparwar, Arjang UNSPECIFIED UNSPECIFIED UNSPECIFIED Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578078
DOI:	10.1177/03913988211053874
Journal or Publication Title:	Int. J. Artif. Organs
Volume:	45
Number:	4
Page Range:	S. 371 - 379
Date:	2022
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1724-6040
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMBRANE-OXYGENATION; HEART-FAILURE Multiple languages Engineering, Biomedical; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57807