Universität zu Köln

Rink, Svenja, Manthou, Maria Eleni, Arnold, Julia, Grigo, Merle, Dicken, Paulina, Abdulla, Diana Saad Yousif, Bendella, Habib, Nohroudi, Klaus and Angelov, Doychin N. (2021). Motor, sensitive, and vegetative recovery in rats with compressive spinal-cord injury after combined treatment with erythropoietin and whole-body vibration. Restor. Neurol. Neurosci., 39 (2). S. 85 - 101. AMSTERDAM: IOS PRESS. ISSN 1878-3627

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Abstract

Background: Physical therapy with whole body vibration (WBV) following compressive spinal cord injury (SCI) in rats restores density of perisomatic synapses, improves body weight support and leads to a better bladder function. The purpose of the study was to determine whether the combined treatment with WBV plus erythropoietin (EPO) would further improve motor, sensory and vegetative functions after SCI in rats. Methods: Severe compressive SCI at low thoracic level was followed by a single i.p. injection of 2,5 mu g (250 IU) human recombinant EPO. Physical therapy with WBV started on 14th day after injury and continued over a 12-week post injury period. Locomotor recovery, sensitivity tests and urinary bladder scores were analysed at 1, 3, 6, 9, and 12 weeks after SCI. The closing morphological measurements included lesion volume and numbers of axons in the preserved perilesional neural tissue bridges (PNTB). Results: Assessment of motor performance sensitivity and bladder function revealed no significant effects of EPO when compared to the control treatments. EPO treatment neither reduced the lesion volume, nor increased the number of axons in PNTB. Conclusions: The combination of WBV + EPO exerts no positive effects on hind limbs motor performance and bladder function after compressive SCI in rats.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rink, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Manthou, Maria Eleni UNSPECIFIED UNSPECIFIED UNSPECIFIED Arnold, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Grigo, Merle UNSPECIFIED UNSPECIFIED UNSPECIFIED Dicken, Paulina UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdulla, Diana Saad Yousif UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Nohroudi, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578290
DOI:	10.3233/RNN-201120
Journal or Publication Title:	Restor. Neurol. Neurosci.
Volume:	39
Number:	2
Page Range:	S. 85 - 101
Date:	2021
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1878-3627
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECOMBINANT-HUMAN-ERYTHROPOIETIN; NEUROLOGICAL RECOVERY; FUNCTIONAL RECOVERY; CONTUSION; MODEL; PLASTICITY; PROMOTES; THERAPY; PATHWAY; METHYLPREDNISOLONE Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57829