Universität zu Köln

Voggel, Jenny, Lubomirov, Lubomir, Lechner, Felix, Fink, Gregor, Nuesken, Eva, Wohlfarth, Maria, Pfitzer, Gabriele, Shah-Hosseini, Kija ORCID: 0000-0001-9616-6942, Hellmich, Martin, Alcazar, Miguel A. Alejandre, Doetsch, Joerg and Nuesken, Kai-Dietrich (2021). Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction. Am. J. Physiol.-Renal Physiol., 321 (1). S. F93 - 13. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1466

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Abstract

Intrauterine growth restriction (IUGR) due to an adverse intrauterine environment predisposes to arterial hypertension and loss of kidney function. Here, we investigated whether vascular dysregulation in renal interlobar arteries (RIAs) may contribute to hypertensive glomerular damage after IUGR. In rats, IUGR was induced by bilateral uterine vessel ligation. Offspring of nonoperated rats served as controls. From postnatal day 49, blood pressure was telemetrically recorded. On postnatal day 70, we evaluated contractile function in RIAs and mesenteric arteries. In addition, blood, urine, and glomerular parameters as well as renal collagen deposition were analyzed. IUGR RIAs not only showed loss of stretch activation in 9 of 11 arteries and reduced stretch-induced myogenic tone but also showed a shift of the concentration-response relation of acetylcholine-induced relaxation toward lower concentrations. However, IUGR RIAs also exhibited augmented contractions through phenylephrine. Systemic mean arterial pressure [mean difference: 4.8 mmHg (daytime) and 5.7 mmHg (night)], mean glomerular area (IUGR: 9,754 +/- 338 mu m(2) and control: 8,395 +/- 227 mu m(2)), and urinary protein-to-creatinine ratio (IUGR: 1.67 +/- 0.13 g/g and control: 1.26 +/- 0.10 g/g) were elevated after IUGR. We conclude that male IUGR rat offspring may have increased vulnerability toward hypertensive glomerular damage due to loss of myogenic tone and augmented endothelium-dependent relaxation in RIAs. NEW & NOTEWORTHY For the first time, our study presents wire myography data from renal interlobar arteries (RIAs) and mesenteric arteries of young adult rat offspring after intrauterine growth restriction (IUGR). Our data indicate that myogenic tone in RIAs is dysfunctional after IUGR. Furthermore, IUGR offspring suffer from mild arterial hypertension, glomerular hypertrophy, and increased urinary protein-to-creatinine ratio. Dysregulation of vascular tone in RIAs could be an important variable that impacts upon vulnerability toward glomerular injury after IUGR.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Voggel, Jenny UNSPECIFIED UNSPECIFIED UNSPECIFIED Lubomirov, Lubomir UNSPECIFIED UNSPECIFIED UNSPECIFIED Lechner, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlfarth, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfitzer, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah-Hosseini, Kija UNSPECIFIED orcid.org/0000-0001-9616-6942 UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Alcazar, Miguel A. Alejandre UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Kai-Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578354
DOI:	10.1152/ajprenal.00653.2020
Journal or Publication Title:	Am. J. Physiol.-Renal Physiol.
Volume:	321
Number:	1
Page Range:	S. F93 - 13
Date:	2021
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1466
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW-BIRTH-WEIGHT; RENIN-ANGIOTENSIN SYSTEM; BLOOD-PRESSURE; UTEROPLACENTAL INSUFFICIENCY; PLACENTAL INSUFFICIENCY; MOLECULAR-MECHANISMS; ADULT HYPERTENSION; MYOGENIC RESPONSE; NEPHRON DEFICIT; KIDNEY-DISEASE Multiple languages Physiology; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57835