Universität zu Köln

Yildiz, Ipek, Mantz, Melissa ORCID: 0000-0001-7254-5331, Hartmann, Michael ORCID: 0000-0003-4828-958X, Zeier, Tatyana, Kessel, Jana, Thurow, Corinna, Gatz, Christiane, Petzsch, Patrick, Kohrer, Karl and Zeier, Juergen (2021). The mobile SAR signal N-hydroxypipecolic acid induces NPR1-dependent transcriptional reprogramming and immune priming. Plant Physiol., 186 (3). S. 1679 - 1706. CARY: OXFORD UNIV PRESS INC. ISSN 1532-2548

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Abstract

N-hydroxypipecolic acid (NHP) accumulates in the plant foliage in response to a localized microbial attack and induces systemic acquired resistance (SAR) in distant leaf tissue. Previous studies indicated that pathogen inoculation of Arabidopsis (Arabidopsis thaliana) systemically activates SAR-related transcriptional reprogramming and a primed immune status in strict dependence of FLAVIN-DEPENDENT MONOOXYGENASE 1 (FMO1), which mediates the endogenous biosynthesis of NHP. Here, we show that elevations of NHP by exogenous treatment are sufficient to induce a SAR-reminiscent transcriptional response that mobilizes key components of immune surveillance and signal transduction. Exogenous NHP primes Arabidopsis wild-type and NHP-deficient fmo1 plants for a boosted induction of pathogen-triggered defenses, such as the biosynthesis of the stress hormone salicylic acid (SA), accumulation of the phytoalexin camalexin and branched-chain amino acids, as well as expression of defense-related genes. NHP also sensitizes the foliage systemically for enhanced SA-inducible gene expression. NHP-triggered SAR, transcriptional reprogramming, and defense priming are fortified by SA accumulation, and require the function of the transcriptional coregulator NON-EXPRESSOR OF PR GENES1 (NPR1). Our results suggest that NPR1 transduces NHP-activated immune signaling modes with predominantly SA-dependent and minor SA-independent features. They further support the notion that NHP functions as a mobile immune regulator capable of moving independently of active SA signaling between leaves to systemically activate immune responses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yildiz, Ipek UNSPECIFIED UNSPECIFIED UNSPECIFIED Mantz, Melissa UNSPECIFIED orcid.org/0000-0001-7254-5331 UNSPECIFIED Hartmann, Michael UNSPECIFIED orcid.org/0000-0003-4828-958X UNSPECIFIED Zeier, Tatyana UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessel, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Thurow, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatz, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Petzsch, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohrer, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeier, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578373
DOI:	10.1093/plphys/kiab166
Journal or Publication Title:	Plant Physiol.
Volume:	186
Number:	3
Page Range:	S. 1679 - 1706
Date:	2021
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1532-2548
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYSTEMIC ACQUIRED-RESISTANCE; HYDROXY-PIPECOLIC ACID; PROGRAMMED CELL-DEATH; RECEPTOR-LIKE KINASE; SALICYLIC-ACID; DISEASE RESISTANCE; BIOSYNTHESIS; DEFENSE; PROTEIN; NPR1 Multiple languages Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57837