Universität zu Köln

Schenk, Alexander ORCID: 0000-0002-3122-714X, Esser, Tobias, Knoop, Andre, Thevis, Mario, Herden, Jan ORCID: 0000-0002-1667-5200, Heidenreich, Axel, Bloch, Wilhelm, Joisten, Niklas ORCID: 0000-0002-9947-8746 and Zimmer, Philipp (2021). Effect of a Single Bout of Aerobic Exercise on Kynurenine Pathway Metabolites and Inflammatory Markers in Prostate Cancer Patients-A Pilot Randomized Controlled Trial. Metabolites, 11 (1). BASEL: MDPI. ISSN 2218-1989

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Abstract

The kynurenine (KYN) pathway gains growing research interest concerning the genesis, progression and therapy of solid tumors. Previous studies showed exercise-induced effects on metabolite levels along the KYN pathway. Modulations of the KYN pathway might be involved in the positive impact of exercise on prostate cancer progression and mortality. The objective of this trial was to investigate whether a single-physical exercise alters tryptophan (TRP) metabolism and related inflammatory markers in this population. We conducted a randomized controlled trial with 24 patients suffering from prostate cancer. While the control group remained inactive, the intervention group performed a 30-min aerobic exercise on a bicycle ergometer at 75% of individual VO2peak. Before (t0) and directly after the exercise intervention (t1) KYN, TRP, kynurenic acid, quinolinic acid as well as various inflammation markers (IL6, TNF-alpha, TGF-beta) were measured in blood serum. At baseline, the present sample showed robust correlations between TRP, KYN, quinolinic acid and inflammatory markers. Regarding the exercise intervention, interaction effects for TRP, the KYN/TRP ratio and TGF-beta were observed. The results show for the first time that acute physical exercise impacts TRP metabolism in prostate cancer patients. Moreover, baseline associations underline the relationship between inflammation and the KYN pathway in prostate cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schenk, Alexander UNSPECIFIED orcid.org/0000-0002-3122-714X UNSPECIFIED Esser, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Knoop, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Herden, Jan UNSPECIFIED orcid.org/0000-0002-1667-5200 UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Joisten, Niklas UNSPECIFIED orcid.org/0000-0002-9947-8746 UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578536
DOI:	10.3390/metabo11010004
Journal or Publication Title:	Metabolites
Volume:	11
Number:	1
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2218-1989
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDOLEAMINE 2,3-DIOXYGENASE; TRYPTOPHAN-METABOLISM; ENDURANCE EXERCISE; TUMOR-GROWTH; TGF-BETA; EXPRESSION; INHIBITION; MECHANISMS; RESISTANCE; INDUCTION Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57853