Universität zu Köln

Kohle, Felix ORCID: 0000-0002-4429-0367, Sprenger, Alina, Klein, Ines, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Lehmann, Helmar C. (2021). Nerve conductions studies in experimental models of autoimmune neuritis: A meta-analysis and guideline. J. Neuroimmunol., 352. AMSTERDAM: ELSEVIER. ISSN 1872-8421

Full text not available from this repository.

Abstract

Nerve conduction studies (NCS) are essential to assess peripheral nerve fiber function in research models of immune-mediated neuritis. However, the current lack of standard protocols and reference values impedes data comparability across models and studies. We performed a systematic review and subsequent meta-analysis of the last 30 years of NCS of immune-mediated neuritis in Lewis-rats. Twenty-six papers met the inclusion criteria for meta-analysis. Extracted data showed considerable heterogeneity of recorded nerve conduction velocity (NCV) and compound muscle action potential (CMAP). Studies also significantly differed in terms of technical, methodical, and data reporting issues. The heterogeneity of the underlying studies emphasizes the need for standardization when conducting and reporting NCS in rats. We provide normative values for NCS of the sciatic nerve of Lewis rats and propose seven items that should be addressed when NCS are performed when studying immune paradigms in Lewis rats.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kohle, Felix UNSPECIFIED orcid.org/0000-0002-4429-0367 UNSPECIFIED Sprenger, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-578915
DOI:	10.1016/j.jneuroim.2020.577470
Journal or Publication Title:	J. Neuroimmunol.
Volume:	352
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-8421
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL ALLERGIC NEURITIS; ANIMAL-MODEL; ACTION-POTENTIALS; OPTIMAL DISTANCE; LEWIS RATS; TEMPERATURE; THERAPY; VELOCITY; ANTIBODY; GROWTH Multiple languages Immunology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57891