Augustin, Max ORCID: 0000-0002-2300-9337, Schommers, Philipp ORCID: 0000-0003-3375-6800, Stecher, Melanie, Dewald, Felix, Gieselmann, Lutz, Gruell, Henning, Horn, Carola, Vanshylla, Kanika ORCID: 0000-0003-4552-9170, Di Cristanziano, Veronica, Osebold, Luise, Roventa, Maria, Riaz, Toqeer, Tschernoster, Nikolai, Altmueller, Janine, Rose, Leonard, Salomon, Susanne, Priesner, Vanessa, Luers, Jan Christoffer, Albus, Christian, Rosenkranz, Stephan, Gathof, Birgit, Faetkenheuer, Gerd, Hallek, Michael, Klein, Florian, Suarez, Isabelle and Lehmann, Clara (2021). Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg. Health-Eur., 6. AMSTERDAM: ELSEVIER. ISSN 2666-7762

Full text not available from this repository.

Abstract

Background: While the leading symptoms during coronavirus disease 2019 (COVID-19) are acute and the majority of patients fully recover, a significant fraction of patients now increasingly experience long-term health consequences. However, most data available focus on health-related events after severe infection and hospitalisation. We present a longitudinal, prospective analysis of health consequences in patients who initially presented with no or minor symptoms of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection. Hence, we focus on mild COVID-19 in non-hospitalised patients. Methods: 958 Patients with confirmed SARS-CoV-2 infection were observed from April 6th to December 2nd 2020 for long-term symptoms and SARS-CoV-2 antibodies. We identified anosmia, ageusia, fatigue or shortness of breath as most common, persisting symptoms at month 4 and 7 and summarised presence of such long-term health consequences as post-COVID syndrome (PCS). Predictors of long-term symptoms were assessed using an uni- and multivariable logistic regression model. Findings: We observed 442 and 353 patients over four and seven months after symptom onset, respectively. Four months post SARS-CoV-2 infection, 8.6% (38/442) of patients presented with shortness of breath, 12.4% (55/442) with anosmia, 11.1% (49/442) with ageusia and 9.7% (43/442) with fatigue. At least one of these characteristic symptoms was present in 27.8% (123/442) and 34.8% (123/353) at month 4 and 7 post-infection, respectively. A lower baseline level of SARS-CoV-2 IgG, anosmia and diarrhoea during acute COVID-19 were associated with higher risk to develop long-term symptoms. Interpretation: The on-going presence of either shortness of breath, anosmia, ageusia or fatigue as long-lasting symptoms even in non-hospitalised patients was observed at four and seven months post-infection and summarised as post-COVID syndrome (PCS). The continued assessment of patients with PCS will become a major task to define and mitigate the socioeconomic and medical long-term effects of COVID-19. (C) 2021 The Authors. Published by Elsevier Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Augustin, MaxUNSPECIFIEDorcid.org/0000-0002-2300-9337UNSPECIFIED
Schommers, PhilippUNSPECIFIEDorcid.org/0000-0003-3375-6800UNSPECIFIED
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dewald, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gieselmann, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruell, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanshylla, KanikaUNSPECIFIEDorcid.org/0000-0003-4552-9170UNSPECIFIED
Di Cristanziano, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osebold, LuiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roventa, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riaz, ToqeerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschernoster, NikolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altmueller, JanineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rose, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salomon, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priesner, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luers, Jan ChristofferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albus, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenkranz, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gathof, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hallek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suarez, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-580932
DOI: 10.1016/j.lanepe.2021.100122
Journal or Publication Title: Lancet Reg. Health-Eur.
Volume: 6
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 2666-7762
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHRONIC FATIGUEMultiple languages
Health Care Sciences & Services; Public, Environmental & Occupational HealthMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58093

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item