Tadepalle, Nimesha and Rugarli, Elena, I (2021). Lipid Droplets in the Pathogenesis of Hereditary Spastic Paraplegia. Front. Mol. Biosci., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-889X
Full text not available from this repository.Abstract
Hereditary spastic paraplegias (HSPs) are genetically heterogeneous conditions caused by the progressive dying back of the longest axons in the central nervous system, the corticospinal axons. A wealth of data in the last decade has unraveled disturbances of lipid droplet (LD) biogenesis, maturation, turnover and contact sites in cellular and animal models with perturbed expression and function of HSP proteins. As ubiquitous organelles that segregate neutral lipid into a phospholipid monolayer, LDs are at the cross-road of several processes including lipid metabolism and trafficking, energy homeostasis, and stress signaling cascades. However, their role in brain cells, especially in neurons remains enigmatic. Here, we review experimental findings linking LD abnormalities to defective function of proteins encoded by HSP genes, and discuss arising questions in the context of the pathogenesis of HSP.
Item Type: | Journal Article | ||||||||||||
Creators: |
|
||||||||||||
URN: | urn:nbn:de:hbz:38-581147 | ||||||||||||
DOI: | 10.3389/fmolb.2021.673977 | ||||||||||||
Journal or Publication Title: | Front. Mol. Biosci. | ||||||||||||
Volume: | 8 | ||||||||||||
Date: | 2021 | ||||||||||||
Publisher: | FRONTIERS MEDIA SA | ||||||||||||
Place of Publication: | LAUSANNE | ||||||||||||
ISSN: | 2296-889X | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
Uncontrolled Keywords: |
|
||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/58114 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
View Item |