Universität zu Köln

Sildatke, Elena, Schueller, Thomas, Gruendler, Theo O. J., Ullsperger, Markus, Visser-Vandewalle, Veerle, Huys, Daniel ORCID: 0000-0002-9124-4128 and Kuhn, Jens (2021). Error-Related Activity in Striatal Local Field Potentials and Medial Frontal Cortex: Evidence From Patients With Severe Opioid Abuse Disorder. Front. Hum. Neurosci., 14. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5161

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Abstract

For successful goal-directed behavior, a performance monitoring system is essential. It detects behavioral errors and initiates behavioral adaptations to improve performance. Two electrophysiological potentials are known to follow errors in reaction time tasks: the error-related negativity (ERN), which is linked to error processing, and the error positivity (Pe), which is associated with subjective error awareness. Furthermore, the correct-related negativity (CRN) is linked to uncertainty about the response outcome. Here we attempted to identify the involvement of the nucleus accumbens (NAc) in the aforementioned performance monitoring processes. To this end, we simultaneously recorded cortical activity (EEG) and local field potentials (LFP) during a flanker task performed by four patients with severe opioid abuse disorder who underwent electrode implantation in the NAc for deep brain stimulation. We observed significant accuracy-related modulations in the LFPs at the time of the ERN/CRN in two patients and at the time of Pe in three patients. These modulations correlated with the ERN in 2/8, with CRN in 5/8 and with Pe in 6/8, recorded channels, respectively. Our results demonstrate the functional interrelation of striatal and cortical processes in performance monitoring specifically related to error processing and subjective error awareness.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sildatke, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schueller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruendler, Theo O. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullsperger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, Daniel UNSPECIFIED orcid.org/0000-0002-9124-4128 UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581668
DOI:	10.3389/fnhum.2020.627564
Journal or Publication Title:	Front. Hum. Neurosci.
Volume:	14
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5161
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; NUCLEUS-ACCUMBENS; DECISION-MAKING; NEGATIVITY; CINGULATE; UNCERTAINTY; MOTIVATION; COMPONENTS; DYNAMICS; TOOLBOX Multiple languages Neurosciences; Psychology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58166