Universität zu Köln

Schorn, Lara, Fienitz, Tim, Gerstenberg, Maximilian F., Sterner-Kock, Anja, Maul, Alexandra C., Lommen, Julian, Holtmann, Henrik and Rothamel, Daniel (2021). Influence of different carrier materials on biphasic calcium phosphate induced bone regeneration. Clin. Oral Investig., 25 (6). S. 3729 - 3738. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1436-3771

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Abstract

Objectives Biphasic calcium phosphate (BCP) is a bioceramic material successfully used in alloplastic bone augmentation. Despite many advantages, a disadvantage of BCP seems to be a difficult application and position instability. The aim of this study was to determine how different carrier materials influence BCP-induced quantitative and qualitative bone regeneration. Materials and methods A total of 70 critical size defects were set in the frontal bone of 14 domestic pigs (5 each) and filled randomly with either BCP alone (BCP), BCP in combination with nano-hydroxyapatite (BCP + NHA), BCP embedded in native porcine type I/III collagen blocks (BCP + C), autologous bone (AB), or were left empty (ED). Specimens were harvested after 4 and 8 weeks and were evaluated histologically as well as histomorphometrically. Results Significantly lowest rate of new bone formation was found in ED (p = < 0.001) and BCP + NHA groups (p = 0.05). After 8 weeks, the highest percentage of new bone formation was observed in the BCP + C group. Fibrous matrix was detected highest in BCP alone. The lowest residual bone substitute material was found in BCP + C after 8 weeks. Conclusions BCP-induced bone regeneration is indeed affected by different carrier types. Surface morphology and bioactive characteristics influence osseointegration and new bone formation in vivo. The combination of type I/III collagen seems most suitable for qualitative and quantitative bone regeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schorn, Lara UNSPECIFIED UNSPECIFIED UNSPECIFIED Fienitz, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerstenberg, Maximilian F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sterner-Kock, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Maul, Alexandra C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lommen, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmann, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581932
DOI:	10.1007/s00784-020-03700-y
Journal or Publication Title:	Clin. Oral Investig.
Volume:	25
Number:	6
Page Range:	S. 3729 - 3738
Date:	2021
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1436-3771
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Dentistry, Oral Surgery & Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58193