Universität zu Köln

Lemberg, Marius K. and Strisovsky, Kvido (2021). Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms. Mol. Cell, 81 (12). S. 2507 - 2520. CAMBRIDGE: CELL PRESS. ISSN 1097-4164

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Abstract

Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to understand how defective proteins are recognized and extracted from cellular organelles to be degraded in the cytoplasm. The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway is the best-understood organellar protein quality control system. Here, we review new insights into the mechanism of recognition and retrotranslocation of client proteins in ERAD. In addition to the membrane-integral ERAD E3 ubiquitin ligases, we highlight one protein family that is remarkably often involved in various aspects of membrane protein quality control and protein dislocation: the rhomboid superfamily, which includes derlins and intramembrane serine proteases. Rhomboid-like proteins have been found to control protein homeostasis in the ER, but also in other eukaryotic organelles and in bacteria, pointing toward conserved principles of membrane protein quality control across organelles and evolution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lemberg, Marius K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Strisovsky, Kvido UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581999
DOI:	10.1016/j.molcel.2021.05.004
Journal or Publication Title:	Mol. Cell
Volume:	81
Number:	12
Page Range:	S. 2507 - 2520
Date:	2021
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4164
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETICULUM-ASSOCIATED DEGRADATION; SIGNAL PEPTIDE PEPTIDASE; CLASS-I MOLECULES; ENDOPLASMIC-RETICULUM; QUALITY-CONTROL; MEMBRANE-PROTEIN; UBIQUITIN-LIGASE; MISFOLDED GLYCOPROTEINS; 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE; SREBP CLEAVAGE Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58199