Universität zu Köln

Zopfs, David, Reimer, Robert Peter, Sonnabend, Kristina ORCID: 0000-0003-3064-0247, Rinneburger, Miriam ORCID: 0000-0003-3980-931X, Hentschke, Clemens M., Persigehl, Thorsten, Lennartz, Simon and Grosse Hokamp, Nils (2021). Intraindividual Consistency of Iodine Concentration in Dual-Energy Computed Tomography of the Chest and Abdomen. Invest. Radiol., 56 (3). S. 181 - 188. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0210

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Abstract

Objectives Dual-energy computed tomography (DECT)-derived quantification of iodine concentration (IC) is increasingly used in oncologic imaging to characterize lesions and evaluate treatment response. However, only limited data are available on intraindividual consistency of IC and its variation. This study investigates the longitudinal reproducibility of IC in organs, vessels, and lymph nodes in a large cohort of healthy patients who underwent repetitive DECT imaging. Materials and Methods A total of 159 patients, who underwent a total of 469 repetitive (range, 2-4), clinically indicated portal-venous phase DECT examinations of the chest and abdomen, were retrospectively included. At time of imaging, macroscopic tumor burden was excluded by follow-up imaging (>= 3 months). Iodine concentration was measured region of interest-based (N = 43) in parenchymatous organs, vessels, lymph nodes, and connective tissue. Normalization of IC to the aorta and to the trigger delay as obtained from bolus tracking was performed. For statistical analysis, intraclass correlation coefficient and modified variation coefficient (MVC) were used to assess intraindividual agreement of IC and its variation between different time points, respectively. Furthermore, t tests and analysis of variance with Tukey-Kramer post hoc test were used. Results The mean intraclass correlation coefficient over all regions of interest was good to excellent (0.642-0.936), irrespective of application of normalization or the normalization technique. Overall, MVC ranged from 1.8% to 25.4%, with significantly lower MVC in data normalized to the aorta (5.8% [1.8%-15.8%]) in comparison with the MVC of not normalized data and data normalized to the trigger delay (P < 0.01 and P = 0.04, respectively). Conclusions Our study confirms intraindividual, longitudinal variation of DECT-derived IC, which varies among vessels, lymph nodes, organs, and connective tissue, following different perfusion characteristics; normalizing to the aorta seems to improve reproducibility when using a constant contrast media injection protocol.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zopfs, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Reimer, Robert Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Sonnabend, Kristina UNSPECIFIED orcid.org/0000-0003-3064-0247 UNSPECIFIED Rinneburger, Miriam UNSPECIFIED orcid.org/0000-0003-3980-931X UNSPECIFIED Hentschke, Clemens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennartz, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Grosse Hokamp, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582663
DOI:	10.1097/RLI.0000000000000724
Journal or Publication Title:	Invest. Radiol.
Volume:	56
Number:	3
Page Range:	S. 181 - 188
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-0210
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58266