Universität zu Köln

Hensel, Lukas, Tscherpel, Caroline, Freytag, Jana, Ritter, Stella, Rehme, Anne K., Volz, Lukas J., Eickhoff, Simon B., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian (2021). Connectivity-Related Roles of Contralesional Brain Regions for Motor Performance Early after Stroke. Cereb. Cortex, 31 (2). S. 993 - 1008. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Hemiparesis after stroke is associated with increased neural activity not only in the lesioned but also in the contralesional hemisphere. While most studies have focused on the role of contralesional primary motor cortex (M1) activity for motor performance, data on other areas within the unaffected hemisphere are scarce, especially early after stroke. We here combined functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) to elucidate the contribution of contralesional M1, dorsal premotor cortex (dPMC), and anterior intraparietal sulcus (aIPS) for the stroke-affected hand within the first 10 days after stroke. We used online TMS to interfere with neural activity at subject-specific fMRI coordinates while recording 3D movement kinematics. Interfering with aIPS activity improved tapping performance in patients, but not healthy controls, suggesting a maladaptive role of this region early poststroke. Analyzing effective connectivity parameters using a Lasso prediction model revealed that behavioral TMS effects were predicted by the coupling of the stimulated aIPS with dPMC and ipsilesional M1. In conclusion, we found a strong link between patterns of frontoparietal connectivity and TMS effects, indicating a detrimental influence of the contralesional aIPS on motor performance early after stroke.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hensel, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Freytag, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritter, Stella UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehme, Anne K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Volz, Lukas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582817
DOI:	10.1093/cercor/bhaa270
Journal or Publication Title:	Cereb. Cortex
Volume:	31
Number:	2
Page Range:	S. 993 - 1008
Date:	2021
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; NETWORK CONNECTIVITY; CORTICAL CONNECTIVITY; INTRAPARIETAL CORTEX; NEURAL ACTIVITY; HAND MOVEMENTS; RECOVERY; FMRI; REORGANIZATION; REPRESENTATION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58281