Universität zu Köln

Zar, Tahira, Tschernatsch, Marlene, Hero, Barbara, Lang, Bethan, Preissner, Klaus T. and Blaes, Franz (2021). NK Cell-mediated Neuroblastoma Cell Lysis is Enhanced by IgG From Patients With Pediatric Opsoclonus-Myoclonus Syndrome. J. Pediatr. Hematol. Oncol., 43 (2). S. E176 - 4. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-3678

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Abstract

Pediatric opsoclonus-myoclonussyndrome (OMS) is a rare autoimmune disorder of which 50% are associated with neuroblastoma (NB). We investigated whether surface-binding autoantibodies in OMS can enhance natural killer (NK) cell-mediated cytotoxicity in these patients. OMS immunoglobulin G (IgG) bound to NB cell lines and NK cell-mediated cytotoxicity to NB cells was enhanced after preincubation with OMS-IgG, but not IgG from NB without OMS or healthy controls. Activation of NK cells by surface-binding autoantibodies may be an additional mechanism of antitumor immunity in children with NB and OMS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zar, Tahira UNSPECIFIED UNSPECIFIED UNSPECIFIED Tschernatsch, Marlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Hero, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Bethan UNSPECIFIED UNSPECIFIED UNSPECIFIED Preissner, Klaus T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaes, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582975
DOI:	10.1097/MPH.0000000000001953
Journal or Publication Title:	J. Pediatr. Hematol. Oncol.
Volume:	43
Number:	2
Page Range:	S. E176 - 4
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-3678
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Oncology; Hematology; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58297