Universität zu Köln

Varesi, Angelica ORCID: 0000-0002-1246-2320, Deumer, Undine-Sophie, Ananth, Sanjana and Ricevuti, Giovanni (2021). The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications. J. Clin. Med., 10 (21). BASEL: MDPI. ISSN 2077-0383

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Abstract

The well-known symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are chronic pain, cognitive dysfunction, post-exertional malaise and severe fatigue. Another class of symptoms commonly reported in the context of ME/CFS are gastrointestinal (GI) problems. These may occur due to comorbidities such as Crohn's disease or irritable bowel syndrome (IBS), or as a symptom of ME/CFS itself due to an interruption of the complex interplay between the gut microbiota (GM) and the host GI tract. An altered composition and overall decrease in diversity of GM has been observed in ME/CFS cases compared to controls. In this review, we reflect on genetics, infections, and other influences that may factor into the alterations seen in the GM of ME/CFS individuals, we discuss consequences arising from these changes, and we contemplate the therapeutic potential of treating the gut to alleviate ME/CFS symptoms holistically.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Varesi, Angelica UNSPECIFIED orcid.org/0000-0002-1246-2320 UNSPECIFIED Deumer, Undine-Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Ananth, Sanjana UNSPECIFIED UNSPECIFIED UNSPECIFIED Ricevuti, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582996
DOI:	10.3390/jcm10215077
Journal or Publication Title:	J. Clin. Med.
Volume:	10
Number:	21
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IRRITABLE-BOWEL-SYNDROME; CHAIN FATTY-ACIDS; PARVOVIRUS B19 INFECTION; CELL-MEDIATED-IMMUNITY; FECAL MICROBIOTA; INTESTINAL MICROBIOTA; NITROSATIVE STRESS; SYNDROME CFS; BACTERIAL TRANSLOCATION; CHRONIC INFLAMMATION Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58299