Universität zu Köln

Waldvogel, Ann-Marie and Pfenninger, Markus ORCID: 0000-0002-1547-7245 (2021). Temperature dependence of spontaneous mutation rates. Genome Res., 31 (9). S. 1582 - 1590. COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. ISSN 1549-5469

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Abstract

Mutation is the source of genetic variation and the fundament of evolution. Temperature has long been suggested to have a direct impact on realized spontaneous mutation rates. If mutation rates vary in response to environmental conditions, such as the variation of the ambient temperature through space and time, they should no longer be described as species-specific constants. By combining mutation accumulation with whole-genome sequencing in a multicellular organism, we provide empirical support to reject the null hypothesis of a constant, temperature-independent mutation rate. Instead, mutation rates depended on temperature in a U-shaped manner with increasing rates toward both temperature extremes. This relation has important implications for mutation-dependent processes in molecular evolution, processes shaping the evolution of mutation rates, and even the evolution of biodiversity as such.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Waldvogel, Ann-Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfenninger, Markus UNSPECIFIED orcid.org/0000-0002-1547-7245 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-583008
DOI:	10.1101/gr.275168.120
Journal or Publication Title:	Genome Res.
Volume:	31
Number:	9
Page Range:	S. 1582 - 1590
Date:	2021
Publisher:	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Place of Publication:	COLD SPRING HARBOR
ISSN:	1549-5469
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENERATION TIME; MOLECULAR EVOLUTION; LABORATORY CULTURES; BODY-SIZE; DROSOPHILA; ACCUMULATION; PATTERNS; STRESS; GENOME; CAENORHABDITIS Multiple languages Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58300