Universität zu Köln

Ma, Ka-Wai, Niu, Yulong, Jia, Yong, Ordon, Jana ORCID: 0000-0001-8764-6418, Copeland, Charles ORCID: 0000-0001-8535-8615, Emonet, Aurelia, Geldner, Niko ORCID: 0000-0002-2300-9644, Guan, Rui, Stolze, Sara Christina ORCID: 0000-0002-1421-9703, Nakagami, Hirofumi ORCID: 0000-0003-2569-7062, Garrido-Oter, Ruben and Schulze-Lefert, Paul (2021). Coordination of microbe-host homeostasis by crosstalk with plant innate immunity. Nat. Plants, 7 (6). S. 814 - 846. BERLIN: NATURE RESEARCH. ISSN 2055-0278

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Abstract

Plants grown in natural soil are colonized by phylogenetically structured communities of microbes known as the microbiota. Individual microbes can activate microbe-associated molecular pattern (MAMP)-triggered immunity (MTI), which limits pathogen proliferation but curtails plant growth, a phenomenon known as the growth-defence trade-off. Here, we report that, in monoassociations, 41% (62 out of 151) of taxonomically diverse root bacterial commensals suppress Arabidopsis thaliana root growth inhibition (RGI) triggered by immune-stimulating MAMPs or damage-associated molecular patterns. Amplicon sequencing of bacterial 16S rRNA genes reveals that immune activation alters the profile of synthetic communities (SynComs) comprising RGI-non-suppressive strains, whereas the presence of RGI-suppressive strains attenuates this effect. Root colonization by SynComs with different complexities and RGI-suppressive activities alters the expression of 174 core host genes, with functions related to root development and nutrient transport. Furthermore, RGI-suppressive SynComs specifically downregulate a subset of immune-related genes. Precolonization of plants with RGI-suppressive SynComs, or mutation of one commensal-downregulated transcription factor, MYB15, renders the plants more susceptible to opportunistic Pseudomonas pathogens. Our results suggest that RGI-non-suppressive and RGI-suppressive root commensals modulate host susceptibility to pathogens by either eliciting or dampening MTI responses, respectively. This interplay buffers the plant immune system against pathogen perturbation and defence-associated growth inhibition, ultimately leading to commensal-host homeostasis. Plants evolved powerful mechanisms to fight against pathogenic microorganisms. So how can they accept and even favour the presence of growth-promoting fungi or bacteria? Here, the authors show that helpful commensal bacteria can suppress part of the plant innate immune system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ma, Ka-Wai UNSPECIFIED UNSPECIFIED UNSPECIFIED Niu, Yulong UNSPECIFIED UNSPECIFIED UNSPECIFIED Jia, Yong UNSPECIFIED UNSPECIFIED UNSPECIFIED Ordon, Jana UNSPECIFIED orcid.org/0000-0001-8764-6418 UNSPECIFIED Copeland, Charles UNSPECIFIED orcid.org/0000-0001-8535-8615 UNSPECIFIED Emonet, Aurelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Geldner, Niko UNSPECIFIED orcid.org/0000-0002-2300-9644 UNSPECIFIED Guan, Rui UNSPECIFIED UNSPECIFIED UNSPECIFIED Stolze, Sara Christina UNSPECIFIED orcid.org/0000-0002-1421-9703 UNSPECIFIED Nakagami, Hirofumi UNSPECIFIED orcid.org/0000-0003-2569-7062 UNSPECIFIED Garrido-Oter, Ruben UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulze-Lefert, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-583022
DOI:	10.1038/s41477-021-00920-2
Journal or Publication Title:	Nat. Plants
Volume:	7
Number:	6
Page Range:	S. 814 - 846
Date:	2021
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2055-0278
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ARABIDOPSIS-THALIANA; ROOT MICROBIOTA; RESPONSES; GROWTH; ACID; RESISTANCE; EXPRESSION; NUTRITION; PATTERNS; PACKAGE Multiple languages Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58302