Universität zu Köln

Heusser, Karsten ORCID: 0000-0002-2571-5585, Heusser, Ramona, Jordan, Jens, Urechie, Vasile, Diedrich, Andre and Tank, Jens (2021). Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation. Front. Neurosci., 15. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-453X

Full text not available from this repository.

Abstract

Arterial baroreflex assessment using vasoactive substances enables investigators to collect data pairs over a wide range of blood pressures and reflex reactions. These data pairs relate intervals between heartbeats or sympathetic neural activity to blood pressure values. In an X-Y plot the data points scatter around a sigmoidal curve. After fitting the parameters of a sigmoidal function to the data, the graph's characteristics represent a rather comprehensive quantitative reflex description. Variants of the 4-parameter Boltzmann sigmoidal equation are widely used for curve fitting. Unfortunately, their 'slope parameters' do not correspond to the graph's actual slope which complicates the analysis and bears the risk of misreporting. We propose a modified Boltzmann sigmoidal function with preserved goodness of fit whose parameters are one-to-one equivalent to the sigmoidal curve's characteristics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heusser, Karsten UNSPECIFIED orcid.org/0000-0002-2571-5585 UNSPECIFIED Heusser, Ramona UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Urechie, Vasile UNSPECIFIED UNSPECIFIED UNSPECIFIED Diedrich, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584814
DOI:	10.3389/fnins.2021.697582
Journal or Publication Title:	Front. Neurosci.
Volume:	15
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-453X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYMPATHETIC-NERVE ACTIVITY; HEART-RATE; BARORECEPTOR REFLEX; PERIAQUEDUCTAL GRAY; ACUTE SHIFTS; SENSITIVITY; RESPONSES; ARTERIAL; LESIONS; RABBIT Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58481