Universität zu Köln

Wegner, Joanna, Karbach, Susanne, Drosos, Ioannis ORCID: 0000-0002-7437-8896, Schnorbus, Boris, Muxel, Selina, Schmidt, Frank, Wenzel, Philip ORCID: 0000-0002-5397-2781, Waisman, Ari, Munzel, Thomas, Gori, Tommaso and von Stebut, Esther (2022). TNF-alpha blockade may lead to improvement of vascular function in psoriasis patients. Exp. Dermatol., 31 (2). S. 237 - 242. HOBOKEN: WILEY. ISSN 1600-0625

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Abstract

Psoriasis is one of the most common chronic inflammatory skin diseases and at the same time a risk factor for cardiovascular disease. Interleukin-17A (IL-17A)-mediated inflammation in psoriasis may lead to vascular dysfunction. This study aimed at investigating whether anti-inflammatory treatment by tumor necrosis factor (TNF)-alpha blockade alters vascular function in psoriasis patients. A total of 11 patients with psoriasis who underwent treatment with either adalimumab (n = 8) or etanercept (n = 3), 10 healthy control individuals and 14 patients with coronary artery disease (CAD) were included in this study. Treatment response was assessed using the Psoriasis Area and Severity Index (PASI) score. Endothelial reactivity and resting endothelium-dependent vascular tone were assessed by ultrasound measurement of flow-mediated dilation (FMD) and low-flow-mediated constriction (l-FMC), respectively. FMD was slightly impaired in psoriasis patients compared to healthy controls. Anti-TNF-alpha treatment did not significantly change FMD levels. Psoriasis patients showed a trend towards increased baseline vascular activity compared to healthy controls. Anti-TNF-alpha treatment significantly improved l-FMC in psoriasis patients. Noteworthy, both FMD and l-FMC in psoriasis patients were comparable to those in patients with CAD; however, an important influence of age differences between the groups or co-existent classical cardiovascular risk factors on FMD and l-FMC cannot be ruled out by our small study. The results suggest that anti-inflammatory treatment with TNF-alpha blockade improves vascular function in patients with psoriasis, mainly by altering baseline vascular tone. Further studies will be necessary to establish the potentially protective impact of anti-inflammatory therapy on vascular function in patients with chronic inflammatory diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wegner, Joanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Karbach, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Drosos, Ioannis UNSPECIFIED orcid.org/0000-0002-7437-8896 UNSPECIFIED Schnorbus, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Muxel, Selina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenzel, Philip UNSPECIFIED orcid.org/0000-0002-5397-2781 UNSPECIFIED Waisman, Ari UNSPECIFIED UNSPECIFIED UNSPECIFIED Munzel, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gori, Tommaso UNSPECIFIED UNSPECIFIED UNSPECIFIED von Stebut, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-585084
DOI:	10.1111/exd.14452
Journal or Publication Title:	Exp. Dermatol.
Volume:	31
Number:	2
Page Range:	S. 237 - 242
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0625
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL DYSFUNCTION; RISK; CONSTRICTION; MORTALITY; DISEASE; COHORT Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58508