Hohn, Andreas, Baumann, Andreas, Pietroschinsky, Eva, Franklin, Jeremy, Illerhaus, Anja, Buchwald, Dirk, Hinkelbein, Jochen, Zahn, Peter K. and Annecke, Thorsten (2021). Hemoadsorption: effective in reducing circulating fragments of the endothelial glycocalyx during cardiopulmonary bypass in patients undergoing on-pump cardiac surgery? Minerva Anestesiol., 87 (1). S. 35 - 43. TURIN: EDIZIONI MINERVA MEDICA. ISSN 1827-1596

Full text not available from this repository.

Abstract

BACKGROUND: The vascular endothelial glycocalyx is susceptible to ischemia and hypoxia. Released soluble components of the endothelial glycocalyx (EG) have been identified as potential damage associated molecular patterns (DAMPs) able to enhance an ongoing inflammatory response. Shedding of the EG has been associated with released atrial-natriuretic peptide (ANP) during cardiac surgery procedures. A novel hemoadsorption technique (CytoSorb (R)) has been shown to effectively remove molecules up to 55 kDa unspecifically from circulation. It is not known whether ANP or glycocalyx components can be removed successfully by this technique. METHODS: In 15 patients undergoing on-pump cardiac surgery, the hemoadsorption device was integrated in the cardiopulmonary bypass (CPB) circuit. Pre- and post-adsorber concentrations ofANP, heparan sulphate (HEP), syndecan-1 (SYN) and hyaluronan (HYA) were measured at 10 (T1), 30 (T2), and 60 (T3) minutes after aortic cross-clamping and complete CPB. RESULTS: Hemoadsorption significantly reduced mean HEP concentrations (-157.5 [333.4] ng/mL; P<0.001) post adsorber. For ANP and SYN no statistically significant changes were detected whereas mean [SD] HYA concentrations even increased significantly (+21.6 [43.0] ng/mL; P<0.001) post adsorber. CONCLUSIONS: In this study representing a real-life scenario, we could demonstrate that the novel hemoadsorption device (CytoSorbe (R)) was able to effectively adsorb HEP from the circulation if integrated in a CPB circuit. However, blood concentrations of HYA, SYN, and ANP could not be reduced during CPB in our investigation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hohn, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumann, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pietroschinsky, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franklin, JeremyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Illerhaus, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchwald, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinkelbein, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zahn, Peter K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Annecke, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-585174
DOI: 10.23736/S0375-9393.20.14525-5
Journal or Publication Title: Minerva Anestesiol.
Volume: 87
Number: 1
Page Range: S. 35 - 43
Date: 2021
Publisher: EDIZIONI MINERVA MEDICA
Place of Publication: TURIN
ISSN: 1827-1596
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HYALURONAN; DEGRADATION; SYNDECAN-1; SEVOFLURANE; ISCHEMIAMultiple languages
Anesthesiology; Critical Care MedicineMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58517

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item