Universität zu Köln

Giacobbe, Daniele R., Magnasco, Laura ORCID: 0000-0002-6343-3271, Sepulcri, Chiara, Mikulska, Malgorzata, Koehler, Philipp ORCID: 0000-0002-7386-7495, Cornely, Oliver A. and Bassetti, Matteo (2021). Recent advances and future perspectives in the pharmacological treatment of Candida auris infections. Expert Rev. Clin. Pharmacol., 14 (10). S. 1205 - 1221. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1751-2441

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Abstract

Introduction Candida auris is responsible for hospital outbreaks worldwide. Some C. auris isolates may show concomitant resistance to azoles, echinocandins, and polyenes, thereby possibly leaving clinicians with few therapeutic options. Areas covered Antifungal agents both in early and in late phases of clinical development showing anti-C. auris activity. Expert opinion The research on antifungal agents active against C. auris has made important steps forward in recent years: (i) the development of drugs with novel mechanisms of action, such as ibrexafungerp and fosmanogepix, could provide a valid option against C. auris strains resistant to one or more older antifungals, including pan-resistant strains; (ii) rezafungin could allow once weekly administration of an active drug in the case of echinocandin-susceptible isolates, providing an effective outpatient treatment, while at the same time relieving selective pressure on novel classes; (iii) the development of oral formulations could allow step-down therapy and/or early discharge, or even to avoid hospitalization in mild or noninvasive diseases; (iv) according to available data, these novel agents show a good safety profile and a low potential for drug-drug interactions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Giacobbe, Daniele R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Magnasco, Laura UNSPECIFIED orcid.org/0000-0002-6343-3271 UNSPECIFIED Sepulcri, Chiara UNSPECIFIED UNSPECIFIED UNSPECIFIED Mikulska, Malgorzata UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehler, Philipp UNSPECIFIED orcid.org/0000-0002-7386-7495 UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bassetti, Matteo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-585520
DOI:	10.1080/17512433.2021.1949285
Journal or Publication Title:	Expert Rev. Clin. Pharmacol.
Volume:	14
Number:	10
Page Range:	S. 1205 - 1221
Date:	2021
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1751-2441
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLUCAN SYNTHASE INHIBITOR; IN-VITRO ACTIVITY; ALBICANS BIOFILM FORMATION; CRYPTOCOCCUS-NEOFORMANS; BROTH MICRODILUTION; AMPHOTERICIN-B; MURINE MODEL; ANTIFUNGAL; MILTEFOSINE; PHARMACOKINETICS Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58552