Universität zu Köln

Paul, Theresa, Hensel, Lukas, Rehme, Anne K., Tscherpel, Caroline, Eickhoff, Simon B., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Grefkes, Christian ORCID: 0000-0002-1656-720X and Volz, Lukas J. ORCID: 0000-0002-0161-654X (2021). Early motor network connectivity after stroke: An interplay of general reorganization and state-specific compensation. Hum. Brain Mapp., 42 (16). S. 5230 - 5244. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Motor recovery after stroke relies on functional reorganization of the motor network, which is commonly assessed via functional magnetic resonance imaging (fMRI)-based resting-state functional connectivity (rsFC) or task-related effective connectivity (trEC). Measures of either connectivity mode have been shown to successfully explain motor impairment post-stroke, posing the question whether motor impairment is more closely reflected by rsFC or trEC. Moreover, highly similar changes in ipsilesional and interhemispheric motor network connectivity have been reported for both rsFC and trEC after stroke, suggesting that altered rsFC and trEC may capture similar aspects of information integration in the motor network reflecting principle, state-independent mechanisms of network reorganization rather than state-specific compensation strategies. To address this question, we conducted the first direct comparison of rsFC and trEC in a sample of early subacute stroke patients (n = 26, included on average 7.3 days post-stroke). We found that both rsFC and trEC explained motor impairment across patients, stressing the clinical potential of fMRI-based connectivity. Importantly, intrahemispheric connectivity between ipsilesional M1 and premotor areas depended on the activation state, whereas interhemispheric connectivity between homologs was state-independent. From a mechanistic perspective, our results may thus arise from two distinct aspects of motor network plasticity: task-specific compensation within the ipsilesional hemisphere and a more fundamental form of reorganization between hemispheres.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Paul, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Hensel, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehme, Anne K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Volz, Lukas J. UNSPECIFIED orcid.org/0000-0002-0161-654X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-585877
DOI:	10.1002/hbm.25612
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	42
Number:	16
Page Range:	S. 5230 - 5244
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL CONNECTIVITY; CONTRALESIONAL MOTOR; HAND MOVEMENTS; INTERHEMISPHERIC INTERACTIONS; CORTICAL CONNECTIVITY; PREMOTOR CORTEX; MOTION ARTIFACT; NEURAL ACTIVITY; HUMAN BRAIN; RECOVERY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58587