Universität zu Köln

Umlauff, Lisa ORCID: 0000-0003-3590-7238, Weber, Manuel ORCID: 0000-0002-5866-9618, Freitag, Nils ORCID: 0000-0002-4415-5421, Fairman, Ciaran M., Heidenreich, Axel, Bloch, Wilhelm and Schumann, Moritz ORCID: 0000-0001-9605-3489 . Dietary interventions to improve body composition in men treated with androgen deprivation therapy for prostate cancer: a solution for the growing problem? Prostate Cancer Prostatic Dis.. LONDON: SPRINGERNATURE. ISSN 1476-5608

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Abstract

Background Androgen deprivation therapy (ADT) has adverse effects on body composition, including muscle wasting and body fat accumulation, which may be attenuated by nutrition therapy. This systematic review summarises available evidence on the effects of dietary interventions on lean mass, fat mass and body mass index (BMI) in men treated with ADT for prostate cancer. Methods MEDLINE, Embase, Web of Science and ClinicalTrials.org were searched from inception through December 2020. We included all controlled trials evaluating effects of supplementation or dietary interventions on body composition in men with prostate cancer receiving continuous ADT. Methodological quality of the studies was assessed using the Cochrane Collaboration's risk of bias tool. Meta-analysis was performed using a random effects model to calculate standardised mean differences between intervention and comparator groups. (PROSPERO; CRD42020185777). Results Eleven studies (n = 536 participants) were included. Seven studies investigated the effects of dietary advice interventions, e.g. individual or group counselling, and four studies included a nutritional supplement. Eight studies combined the dietary intervention with exercise. Nine studies reported sufficient data for inclusion in the meta-analysis. Dietary advice and supplementation interventions combined were not associated with significant changes in lean mass (0.05 kg; 95% CI: -0.17, 0.26; p = 0.674; n = 355), fat mass (-0.22 kg; 95% CI: -0.45, 0.01; p = 0.064; n = 336) or BMI (-0.16 kg*m(-2); 95% CI: -0.37, 0.04; p = 0.121; n = 399). Dietary advice interventions alone were associated with a significant fat mass reduction (-0.29 kg; 95% CI: -0.54, -0.03; p = 0.028; n = 266). Conclusions Most studies were dietary advice interventions targeting caloric restriction, which showed the potential to reduce fat mass but did not increase lean mass in men treated with ADT. Future interventions should investigate whether a combination of dietary advice and protein supplementation with concomitant resistance exercise could counteract ADT-induced muscle wasting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Umlauff, Lisa UNSPECIFIED orcid.org/0000-0003-3590-7238 UNSPECIFIED Weber, Manuel UNSPECIFIED orcid.org/0000-0002-5866-9618 UNSPECIFIED Freitag, Nils UNSPECIFIED orcid.org/0000-0002-4415-5421 UNSPECIFIED Fairman, Ciaran M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumann, Moritz UNSPECIFIED orcid.org/0000-0001-9605-3489 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-586948
DOI:	10.1038/s41391-021-00411-7
Journal or Publication Title:	Prostate Cancer Prostatic Dis.
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5608
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIFE-STYLE INTERVENTION; RESISTANCE EXERCISE; SKELETAL-MUSCLE; PROTEIN; WEIGHT; SUPPLEMENTATION; CASTRATION; GUIDELINES; SARCOPENIA; EFFICACY Multiple languages Oncology; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58694