Universität zu Köln

Fu, Yan ORCID: 0000-0002-4942-159X, Zou, Tiantian, Shen, Xiaotian, Nelson, Peter J., Li, Jiahui, Wu, Chao, Yang, Jimeng, Zheng, Yan, Bruns, Christiane, Zhao, Yue, Qin, Lunxiu and Dong, Qiongzhu (2021). Lipid metabolism in cancer progression and therapeutic strategies. MedComm, 2 (1). S. 27 - 60. HOBOKEN: WILEY. ISSN 2688-2663

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Abstract

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signaling molecules, and source material for the biogenesis of cell membranes. The enhanced synthesis, storage, and uptake of lipids contribute to cancer progression. The rewiring of lipid metabolism in cancer has been linked to the activation of oncogenic signaling pathways and cross talk with the tumor microenvironment. The resulting activity favors the survival and proliferation of tumor cells in the harsh conditions within the tumor. Lipid metabolism also plays a vital role in tumor immunogenicity via effects on the function of the noncancer cells within the tumor microenvironment, especially immune-associated cells. Targeting altered lipid metabolism pathways has shown potential as a promising anticancer therapy. Here, we review recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression, and discuss the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer. This review sheds new light to fully understanding of the role of lipid metabolic reprogramming in the context of cancer and provides valuable clues on therapeutic strategies targeting lipid metabolism in cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fu, Yan UNSPECIFIED orcid.org/0000-0002-4942-159X UNSPECIFIED Zou, Tiantian UNSPECIFIED UNSPECIFIED UNSPECIFIED Shen, Xiaotian UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelson, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Jiahui UNSPECIFIED UNSPECIFIED UNSPECIFIED Wu, Chao UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Jimeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Zheng, Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED Qin, Lunxiu UNSPECIFIED UNSPECIFIED UNSPECIFIED Dong, Qiongzhu UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587055
DOI:	10.1002/mco2.27
Journal or Publication Title:	MedComm
Volume:	2
Number:	1
Page Range:	S. 27 - 60
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2688-2663
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FATTY-ACID SYNTHASE; STEAROYL-COA-DESATURASE; ATP CITRATE LYASE; SPHINGOSINE KINASE 1; ELEMENT-BINDING PROTEINS; HUMAN COLORECTAL-CANCER; CD8(+) T-CELLS; PROSTATE-CANCER; BREAST-CANCER; PHOSPHOLIPASE-D Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58705