Universität zu Köln

Senkal, Evrim, Bagcioglu, Erman, Eryigit, Umut, Erbas, Oytun and Solmaz, Volkan (2021). Exposure to hypertonic solutions during pregnancy induces autism-like behaviors via the NFAT-5 pathway in offspring in a rat model. Physiol. Behav., 240. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-507X

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Abstract

Objectives: to investigate the effects of hyperosmolar state (HS) on immune response and inflammation via the NFAT5 pathway and examine whether immune-mediated conditions trigger autism-like behavior in offspring. Methods: a pregnant rat model was performed by administering hyperosmotic solutions. Pregnant rats were divided into 2 main groups; control (group I) and hyperosmolar groups (group II). Control group rats were given % 0.25 NaCI (tap water) (n = 6), the Hyperosmolar (HO) group was further subdivided into 3 groups as; Group II a rats which were given % 3 hypertonic NaCl (n = 6), Group II b rats were given mineral water (% 3 NaH-CO3+magnesium+calcium content) (n = 6), and Group II c rats were given Ayran (% 0.8 NaCl content) (n = 6). Their offspring were examined for behaviors, biochemical and histological abnormality. Results: in offspring, TNF-alpha, IL-17, NFAT-5, and NGF levels in the brain were significantly higher in hyperosmotic solution groups than in control rats. Exposure of pregnant rats to hyperosmotic solution resulted in autism-like behaviors in their offspring. Through immunohistochemical methods, we found that CA1 and CA2 of the hippocampus indicated decreased number of neurons in hyperosmotic solution groups compared with the control group. Conclusions: our findings once again emphasized that the immune-mediated conditions involved in the pathophysiology of autism. NFAT5 pathway may be a key factor in the development of neuroinflammation by hyperosmotic solutions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Senkal, Evrim UNSPECIFIED UNSPECIFIED UNSPECIFIED Bagcioglu, Erman UNSPECIFIED UNSPECIFIED UNSPECIFIED Eryigit, Umut UNSPECIFIED UNSPECIFIED UNSPECIFIED Erbas, Oytun UNSPECIFIED UNSPECIFIED UNSPECIFIED Solmaz, Volkan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587278
DOI:	10.1016/j.physbeh.2021.113545
Journal or Publication Title:	Physiol. Behav.
Volume:	240
Date:	2021
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-507X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MATERNAL IMMUNE ACTIVATION; SPECTRUM DISORDERS; PRENATAL EXPOSURE; TH17 CELLS; INTERLEUKIN-17A; MACROPHAGES; CHILDREN; BRAIN; IL-17; RISK Multiple languages Psychology, Biological; Behavioral Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58727