Universität zu Köln

Breuer, Saida ORCID: 0000-0003-3723-5762, Kasper, Philipp ORCID: 0000-0002-6218-2239, Vohlen, Christina, Janoschek, Ruth, Hoffmann, Thorben, Appel, Sarah, Mueller-Limberger, Elena, Mesaros, Andrea, Rose-John, Stefan ORCID: 0000-0002-7519-3279, Garbers, Christoph ORCID: 0000-0003-4939-6950, Mueller, Stefan, Lackmann, Jan-Wilm ORCID: 0000-0001-8182-8034, Mahabir, Esther, Doetsch, Joerg, Hucklenbruch-Rother, Eva and Bae-Gartz, Inga ORCID: 0000-0002-4061-503X (2021). Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring. Nutrients, 13 (11). BASEL: MDPI. ISSN 2072-6643

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Abstract

Maternal obesity greatly affects next generations, elevating obesity risk in the offspring through perinatal programming and flawed maternal and newborn nutrition. The exact underlying mechanisms are poorly understood. Interleukin-6 (IL-6) mediates its effects through a membrane-bound receptor or by trans-signaling (tS), which can be inhibited by the soluble form of the co-receptor gp130 (sgp130). As IL-6 tS mediates western-style diet (WSD) effects via chronic low-grade inflammation (LGI) and LGI is an important mediator in brain-adipose tissue communication, this study aims at determining the effects of maternal obesity in a transgenic mouse model of brain-restricted IL-6tS inhibition ((GFAPsgp130)) on offspring's short- and long-term body composition and epigonadal white adipose tissue (egWAT) metabolism. Female wild type (WT) or transgenic mice were fed either standard diet (SD) or WSD pregestationally, during gestation, and lactation. Male offspring received SD from postnatal day (P)21 to P56 and were metabolically challenged with WSD from P56 to P120. At P21, offspring from WT and transgenic dams that were fed WSD displayed increased body weight and egWAT mass, while glucose tolerance testing showed the strongest impairment in (WSD)-W-GFAPsgp130 offspring. Simultaneously, egWAT proteome reveals a characteristic egWAT expression pattern in offspring as a result of maternal conditions. IL-6tS inhibition in transgenic mice was in tendency associated with lower body weight in dams on SD and their respective offspring but blunted by the WSD. In conclusion, maternal nutrition affects offspring's body weight and egWAT metabolism predominantly independent of IL-6tS inhibition, emphasizing the importance of maternal and newborn nutrition for long-term offspring health.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Breuer, Saida UNSPECIFIED orcid.org/0000-0003-3723-5762 UNSPECIFIED Kasper, Philipp UNSPECIFIED orcid.org/0000-0002-6218-2239 UNSPECIFIED Vohlen, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Janoschek, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Thorben UNSPECIFIED UNSPECIFIED UNSPECIFIED Appel, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller-Limberger, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Mesaros, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Rose-John, Stefan UNSPECIFIED orcid.org/0000-0002-7519-3279 UNSPECIFIED Garbers, Christoph UNSPECIFIED orcid.org/0000-0003-4939-6950 UNSPECIFIED Mueller, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lackmann, Jan-Wilm UNSPECIFIED orcid.org/0000-0001-8182-8034 UNSPECIFIED Mahabir, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Hucklenbruch-Rother, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Bae-Gartz, Inga UNSPECIFIED orcid.org/0000-0002-4061-503X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587477
DOI:	10.3390/nu13113735
Journal or Publication Title:	Nutrients
Volume:	13
Number:	11
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6643
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADIPOSE-TISSUE INFLAMMATION; LOW-GRADE INFLAMMATION; SEX-DIFFERENCES; INTERLEUKIN-6; DIET; ENERGY; HOMEOSTASIS; EXPRESSION; PREGNANCY; RECEPTOR Multiple languages Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58747