Universität zu Köln

Fish, Simon, Christidi, Foteini, Karavasilis, Efstratios, Velonakis, Georgios, Kelekis, Nikolaos, Klein, Christoph, Stefanis, Nicholas C. and Smyrnis, Nikolaos (2021). Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity. npj Schizophr., 7 (1). BERLIN: NATURE RESEARCH. ISSN 2334-265X

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Abstract

Chronic cannabis use and schizophrenia are both thought to affect reward processing. While behavioural and neural effects on reward processing have been investigated in both conditions, their interaction has not been studied, although chronic cannabis use is common among these patients. In the present study eighty-nine participants divided into four groups (control chronic cannabis users and non-users; schizophrenia patient cannabis users and non-users) performed a two-choice decision task, preceded by monetary cues (high/low reward/punishment or neutral), while being scanned using functional magnetic resonance imaging. Reward and punishment anticipation resulted in activation of regions of interest including the thalamus, striatum, amygdala and insula. Chronic cannabis use and schizophrenia had opposing effects on reward anticipation sensitivity. More specifically control users and patient non-users showed faster behavioural responses and increased activity in anterior/posterior insula for high magnitude cues compared to control non-users and patient users. The same interaction pattern was observed in the activation of the right thalamus for reward versus punishment cues. This study provided evidence for interaction of chronic cannabis use and schizophrenia on reward processing and highlights the need for future research addressing the significance of this interaction for the pathophysiology of these conditions and its clinical consequences.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fish, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Christidi, Foteini UNSPECIFIED UNSPECIFIED UNSPECIFIED Karavasilis, Efstratios UNSPECIFIED UNSPECIFIED UNSPECIFIED Velonakis, Georgios UNSPECIFIED UNSPECIFIED UNSPECIFIED Kelekis, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Stefanis, Nicholas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyrnis, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-588553
DOI:	10.1038/s41537-021-00163-2
Journal or Publication Title:	npj Schizophr.
Volume:	7
Number:	1
Date:	2021
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2334-265X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL CONNECTIVITY; NUCLEUS-ACCUMBENS; USE DISORDER; ACTIVATION; MONETARY; DYSFUNCTION; RISK; METAANALYSIS; PREDICTION; SYSTEM Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58855